Gamma-glutamylcysteine synthetase
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Gamma-glutamylcysteine synthetase (EC 6.3.2.2) is the first enzyme in the glutathione biosynthesis pathway. It catalyses the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine. The peptide bond in this peptide product is between the carboxylate group of the glutamate and the amino group of the cysteine.[1]
[edit] References
- ^ Njålsson R, Norgren S (2005). "Physiological and pathological aspects of GSH metabolism.". Acta Paediatr 94 (2): 132-7. PMID 15981742.