Moxidectin
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Image:Moxidectin.png |
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| (10E,14E,16E,22Z)-(1R,4S,5′S,6R,6′S,8R,13R,20R,21R,24S)-6′- [(E)-1,3-dimethylbut-1-enyl]-21,24-dihydroxy-4′-methoxyimino- |
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| CAS number 113507-06-5 |
ATC code ? |
| Chemical formula | C37H53NO8 |
| Molecular weight | 639.819 g/mol |
| Bioavailability | ? |
| Metabolism | ? |
| Elimination half-life | ? |
| Excretion | ? |
| Pregnancy category | ? |
| Legal status | ? |
| Routes of administration | ? |
Moxidectin is an active ingredient used in treatments for prevention and control of heartworm and intestinal worms, and can be found in treatments prescribed for animals such as dogs, cats, horses, cattle and sheep. Application methods for moxidectin vary by treatment, and include oral, topical, and injectable solutions.
Moxidectin treats and controls some of the most common internal and external parasites by selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.
Studies of moxidectin show that side effects vary by animal and may be affected by the product’s formulation, application method and dosage. It is important to talk to your veterinarian about which treatment is best to use and how to correctly apply it. If you are an owner of a herding dog, your dog may be avermectin-sensitive, making it more sensitive to common heartworm preventatives, and it is recommended that you discuss appropriate treatments with your veterinarian.
[edit] References
- Moxidectin Facts Web Site
- PubChem Substance Summary: Moxidectin National Center for Biotechnology Information.
- Moxidectin Data Sheet
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