Lactacystin
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Lactacystin is an organic compound naturally synthesized by bacteria of the genus Streptomyces first described in 1991.[1] The first total synthesis of lactacystin was developed by Elias Corey in 1992.[2] The molecule is most commonly used as in biochemistry and cell biology laboratories as a selective inhibitor of the proteasome.[3] The molecule is a lactam, or cyclic amide.
[edit] References
- ^ Omura S, Fujimoto T, Otoguro K, Matsuzaki K, Moriguchi R, Tanaka H, Sasaki Y. (1991). Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells: S. Omura, et al. J. Antibiot. 44(1):113-6.
- ^ "Total Synthesis of Lactacystin" Corey, E. J.; Reichard, G. A. J. Am. Chem. Soc. 1992, 114, 10677.
- ^ Orlowski RZ. (1999). The role of the ubiquitin-proteasome pathway in apoptosis. Cell Death Differ 6: 303-313.
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