Simmonds' disease
From Wikipedia, the free encyclopedia
| ICD-10 | E23.0 |
|---|---|
| DiseasesDB | 11998 |
| MeSH | D007018 |
Simmonds' disease (also Simmonds' syndrome) refers to panhypopituitarism caused by the destruction of the pituitary gland due to infiltrative processes (e.g. lymphocytic), tumours (pituitary adenomas or craniopharyngiomas) or trauma (cranial injury or following surgery).
Sheehan's syndrome is a sub-classification of Simmond's disease occurring specifically in the peripartum period.
[edit] Eponym
It was first described by Morris Simmonds when a patient presented with 'fatal cachexia', although his patient went on to live for 11 more years. [1][2]
[edit] Symptoms
Although cachexia may be present, the disease is characterised by symptoms due to decreased gonadal, thyroidal and adrenal function. These include:
- amenorrhoea or oligomenorrhoea, impotence, loss of libido
- tiredness, hypotension
- waxy skin, loss of body hair
See Hypopituitarism
[edit] References
- ^ Simmonds M, (1914) Dtsch. med. Wschr. 40, 322
- ^ synd/2008 at Who Named It
- Fraser R, Smith PH (1941) QJM. 10:297-330
thyroid Hypothyroidism (Iodine deficiency, Cretinism, Congenital hypothyroidism, Goitre) - Hyperthyroidism (Graves-Basedow disease, Toxic multinodular goitre) - Thyroiditis (De Quervain's thyroiditis, Hashimoto's thyroiditis)
pancreas Diabetes mellitus (type 1, type 2, coma, angiopathy, ketoacidosis, nephropathy, neuropathy, retinopathy) - Zollinger-Ellison syndrome
parathyroid Hypoparathyroidism (Pseudohypoparathyroidism) - Hyperparathyroidism (Primary hyperparathyroidism, Secondary hyperparathyroidism, Tertiary hyperparathyroidism)
pituitary hyperfunction (Acromegaly, Hyperprolactinaemia, Syndrome of inappropriate antidiuretic hormone) - Hypopituitarism (Sheehan's syndrome, Kallmann syndrome, Simmonds' disease, Growth hormone deficiency) - Diabetes insipidus - Hypothalamic-pituitary dysfunction
adrenal Cushing's syndrome (Nelson's syndrome, Pseudo-Cushing's syndrome) - Congenital adrenal hyperplasia (due to 21-hydroxylase deficiency) - Hyperaldosteronism (Conn syndrome, Bartter syndrome) - Adrenal insufficiency (Addison's disease) - Hypoaldosteronism
gonads Polycystic ovary syndrome - 5-alpha-reductase deficiency - Hypogonadism - Delayed puberty - Precocious puberty
other Autoimmune polyendocrine syndrome - Carcinoid syndrome - Laron syndrome - Psychogenic dwarfism - Androgen insensitivity syndrome - Progeria
