Talk:Phencyclidine
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"Many believe PCP to be one of the most dangerous drugs of abuse. Modification of the manufacturing process may yield chemically related analogues capable of producing psychotic effects similar to PCP."
whoa wait a second you need to document these two scentences, ive never read anything like this in a serious medical text.
We need to add in this article that PCP has been for the past 20 years the drug with the most misinformation about it. Things like the scene about it in terminator 1 don't jive with what we know about it at all.
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[edit] Terminator
Mabye I am not reading it correctly, but the Terminator was a robot, and that's why he could punch through glass without feeling it, not because of Phencyclidine use
yes but the cops Thought that's way he chould punch through glass Joeyjojo 04:34, 10 April 2006 (UTC)
[edit] Ashy Larry
Is there any connection between this name for the drug and the character on Chapelle's Show, Ashy Larry?
[edit] Rarest Substance?
>>The drug is mentioned far more than it is actually encountered, being one of the rarest scheduled substances (second to extracted purified mescaline).<<
What's about DMT is it not rare?
Its rare too, but nothing near as rare as "extracted mescaline".
PCP is by no means a "rare" drug in Montreal, Canada, thats for sure. It is usually sold cheaply, in cut powder form. Also, PCP is most commonly referred to as "mesc" on the streets of montreal, which tends to lead to much confusion. As such, in Montreal, many people tend to equate PCP and Mescaline (which IS very rare in Montreal)as the same substance. Morphine 18:56, 16 February 2006 (UTC)
[edit] npov
i've eliminated the "dangerous drugs" comment as well as the "rarest drug" comment. neither have been cited and plenty of time has been given. in my own experience, neither dmt, extracted mescaline, or pcp or particularly rare, but pcp is certainly the least rare of these three- not that my own experience means anything here, but just read the article, its a common inner city drug of abuse. --Heah (talk) 19:15, 21 May 2005 (UTC)
"but pcp is certainly the least rare of these three- not that my own experience means anything here, but just read the article, its a common inner city drug of abuse. --Heah (talk) 19:15, 21 May 2005 (UTC)"
No but it ISNT a common inner city drug of abuse, you are feeding into the propaganda. The amount of abuse of PCP is mythological.
PCP isn't as common as it once was. But in late 70s, PCP was used by about 15% of all 12th graders. This gradely dropped down to about 3-5% which is actually about the level LSD is at.
[edit] Use as veterinarian anaesthetic
David Taylor, the "Zoo Vet" (he wrote a number of books on his experience as veterinarian for exotic animals and is a noted specialist of the care of marine mammals) reports that when the first hypodermic needle handguns appeared (a tremendous improvement for him), they were used with Phencyclidine as an anaesthetic (actually, what was needed was a drug capable of "knocking out" angry, dangerous mammals). He said that low doses of phencyclidine were found to induce erotic dreams in humans (and thus it could be validly suspected that they did the same to large primates such as chimpanzees). He also once used this compound on a zebra, but when the zebra was coming out of anaesthesia, it apparently had terrible nightmares and Taylor decided to never use this compound again on a zebra or other equine animal. He however mentions that the drugs worked well with bears. For the zebra, he had to wait for drugs such as xylazine and etorphine.
I think we need more about the use of phencyclidine as an anaesthetic. I hesitate before copying the above from Taylor (his books are full of funny anecdotes, but he does not explain the matters in very detailed scientific facts or give statistics). Also, I'm no medical or veterinarian doctor (but could perhaps look in databases of medical or veterinarian articles if necessary). However, I think that it would be interesting to mention this usage, the side effects it produced etc.
David.Monniaux 05:43, 29 August 2005 (UTC)
[edit] Dead link
The DEA link is dead 145.18.154.166 13:09, 30 September 2005 (UTC)
Removed the DEA link 146.50.208.168 00:55, 8 October 2005 (UTC)
[edit] embalming fluid
it says something about embalming fluid being put on joints...because they sometimes do.
- No, they don't. See Embalming chemicals. beefman 20:07, 26 August 2006 (UTC)
It's merely a slang term for Phencyclidine. 4.234.39.196 18:39, 30 January 2007 (UTC)
[edit] Police and Firefighters
I adaded a little blurb about the way cops and firefighters talk about ppeople on PCP. I've heard some crazy stories, but don't know whether or not they can be substantiated, which is why I put it into the myth section. I think a section elaborating on the relationship between police and firefighters on the one hand and PCP as this drug that makes people into these superhuman demons on the other might be an interesting addition to the article. By the way, is it true that PCP is really localized to DC and LA? Shaggorama 13:56, 8 December 2005 (UTC)
PCP can also be found on the streets of Chicago and New York. In Chicago it is called "Wicked", "Wicked Sticks", and "Happy Sticks" (Moore Cigarettes dipped in PCP). In New York, it is known as "Leaf" (Mint Leaves) and "Angel Dust".
In Kansas City, MO it is called "Water".
The superhuman demon theory is true. It happens to certain individuals who are already violent without PCP. The PCP magnifies the problems of the individual, and he reacts...sometimes by destroying everything in sight. Others are simply trying to find their way back into this world.
[edit] Use as an adulterant
what is the likelihood of powdered PCP being used as an adulterant in other drugs, for example ecstasy? i have encountered a belief out there that LSD is often adulterated with PCP. is this simply layman's mythology? Morphine 18:45, 16 February 2006 (UTC)
- On tabs there's no room for adulterants. Even if PCP were on an LSD tab it would be so little as to do nothing. It could be sold as E though.
[edit] Pharmacodynamics
The article doesn't say how PCP works. Can anyone add that? Especially as DXM and disassociative refer to them as "working in the same way as PCP"...
PCP is a non-competative antagonist of the N-methyl-D-aspartate class of glutamate receptors. It works by binding to a site inside the receptor pore and blocks the passage of ions when the receptor is activiated. Glutamate is a major excitatory neurotransmitter in the brain and antagonism of the NMDA receptor by PCP results in its effects. Ketamine is also an NMDA receptor antagonist and works in the much the same way, although its affinity to the binding site is about 10X less so its roughly 10X less potent then PCP.
[edit] "Trends" is maybe unfixable.
"" PCP use is extremely prevalent in the Metro Washington DC area, especially in Prince George's County, Maryland and Southeast DC. In the Washington, DC area, it is often referred to as a dipper (cigarette dipped in PCP). PCP production is centered in the greater Los Angeles metropolitan area. Los Angeles-based street gangs, primarily the Crips, continue to distribute PCP to many cities in the United States using their cocaine trafficking operations. These gangs pose a particular problem due to their propensity for violence. During the late 1980s and early 1990s, the widespread availability and use of crack cocaine displaced demand for PCP. More recently, however, reporting suggests that PCP abuse is increasing slightly in many cities, as some crack addicts return to the use of this drug. For instance, the DEA Portland District Office reports a resurgence in the popularity of liquid PCP, also known as "sherm", among Portland area gangs. California street gangs reportedly are responsible for the reemergence of PCP in the Pacific Northwest. On the east coast it is only found in nyc. Mainly sold in Harlem is often distibuted throughout the five boroughs. Treated cigarettes, which have a yellow tint caused by the liquid PCP [called dips], were first observed on the street in 1996, costing between $15 and $20 each. The DEA Philadelphia Field Division also reports that PCP was available readily in the region in 1998. The DEA seized three clandestine PCP laboratories in 2004. ""
There are so many problems here I don't know where to begin. There are no citations. Says production is centered in LA -- I doubt PCP made in LA is supplying East-coast markets; even if it is I doubt very much street gangs like the Crips are responsible. 'Poses a particular problem' is a value judgement. 'Only found in nyc' contradicts the first two sentences, and the widely-documented use of "wet" in the Philadelphia area. 'Mainly sold in Harlem' is a fragment. 'Dips' are described twice. Oh right, now it's in Philadelphia. The last sentence is unclear -- were the labs also in Philadelphia? If so, this contradicts the 'out of LA' theory. Plus, the whole thing is U.S.-centric. Which is not surprising considering the evident mentality of the authors responsible. --CKL
[edit] "Drug Addict" picture
Get rid of it. It seems unecessarily "artistic" and vague. I have doubts that it's even an accurate picture and it's blurred beyond coherency to give it an air of "drugedness". As far as I can tell it's just some one laying down on the floor and the notion that it's someone who is "visibly overdosing" is preposterous because you can't discern that type of thing from an image of a person laying down. It's not giving the reader any new information and is just confusing. I'm not sure who put the picture there or what sort of message they were trying to convey but it's superfluous and unecessary. Find a clearer more reputable picture or get rid of it.
[edit] sign! ¡ ¿ ~~~~
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hopiakuta ; [[ <nowiki> </nowiki> { [[%c2%a1]] [[%c2%bf]] [[ %7e%7e%7e%7e ]] } ;]] 01:31, 18 October 2006 (UTC)
[edit] Not an accurate edit:
- Tupac Shakur mentions PCP in his song "I Ain't Mad at Ya" - "...standin' on the block, wit ya glock, trippin' off sherm..." (As noted above, "sherm" is a slang name for PCP.)
edit:
--no thats slang for cocaine stupid -- -- STP
What are you on about kook, that shits slang for angel dust.
"...As noted above,..."
hopiakuta ; [[ <nowiki> </nowiki> { [[%c2%a1]] [[%c2%bf]] [[ %7e%7e%7e%7e ]] } ;]] 01:31, 18 October 2006 (UTC)
[edit] "In popular culture"
I compacted the "in popular culture" section into a single paragraph; it was beginning to turn into an indiscriminate list of every single time a fictional character takes PCP and something wacky happens. Krimpet 01:43, 25 February 2007 (UTC)
[edit] You're looking at 5 to 10 mandatory
That's PCP. Phencyclidine. Angel dust. You ever seen what this stuff does to kids? 64.109.251.85 20:23, 23 March 2007 (UTC)
PHARMACODYNAMICS
Guys, NMDA receptors (ionosphoros) are all over the brain. Glutamate is one of most important excitatory neurotransmitter in the CNS along with aspartate. Glutamate is an agonist of NMDA receptors. PCP is an "open-channel" agonist of the NMDA receptor. So, if you think about the effects of this chemical, it could NEVER be an antagonist. It just leaves the channel open and that is the reason why is a potent psychotomimetic drug.
JPO.
Sorry, you are wrong. PCP is an NMDA antagonist. Perhaps you would like to review the research?
Javitt DC. Glutamate and Schizophrenia: Phencyclidine, N-Methyl-d-Aspartate Receptors, and Dopamine-Glutamate Interactions. International Review of Neurobiology. 2007;78:69-108. "...phencyclidine (PCP) and ketamine induce psychotic symptoms and neurocognitive disturbances similar to those of schizophrenia by blocking neurotransmission at NMDA-type glutamate receptors."
Faucard R, Armand V, Heron A, Cochois V, Schwartz JC, Arrang JM. N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. Journal of Neurochemistry. 2006 Sep;98(5):1487-96. "The NMDA open-channel blockers phencyclidine (PCP) and MK-801..."
Try doing a PubMed search next time... Meodipt 12:18, 31 March 2007 (UTC)
[edit] Neutrality dispute in "effects" section
This dispute appears to have been resolved. I'm removing the tag. If there are issues with the accuracy of the statements in that section, then affix an appropriate tag and discuss specific concerns on the talk page. TaintedMustard 04:20, 2 April 2007 (UTC)
