Avidity hypothesis

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Avidity hypothesis states that the affinity of the T-cell receptor for the MHC:peptide complex along with the density of the complex provide different signal strength upon binding which in terms dictate the outcome:

1. strong signal leads to negative selection and thus apoptosis
2. weak signal leads to positive selection and thus rescued from apoptosis

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Categories: Cell biology stubs | Wikipedia articles needing context | Wikipedia introduction cleanup

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• This page was last modified 18:12, 9 March 2007 by Wikipedia user Stemonitis. Based on work by Wikipedia user(s) Alaibot and Lkyyun and Anonymous user(s) of Wikipedia.
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