Glucosepane
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Glucosepane is an protein cross-linking product that is the most common protein cross-link found in senescent skin. Glucosepane forms from a glucose-lysine Amadori product reacting with an arginine molecule.
Glucosepane occurs with about twice the frequency in diabetics as is found in non-diabetics. In the extracellular matrix of the skin of a non-diabetic 90-year-old glucosepane accounts for about 50 times the protein cross-linking as all other forms of protein cross-linking [1].
[edit] See also
[edit] References
- ^ Sell DR, Biemel KM, Reihl O, Lederer MO, Strauch CM, Monnier VM (2005). "Glucosepane is a major protein cross-link of the senescent human extracellular matrix. Relationship with diabetes.". JOURNAL OF BIOLOGICAL CHEMISTRY 280 (13): 12310-12315. PMID 15677467.
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