Isomerase
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In biochemistry, an isomerase is any enzyme that catalyses the interconversion of isomers. Isomerases thus catalyze reactions of the form
- A → B
[edit] Nomenclature
The names of isomerases are formed as "substrate isomerase" (for example, enoyl CoA isomerase), or as "substrate type of isomerase" (for example, phosphoglucomutase).
[edit] Classification
Isomerases are classified as EC 5 in the EC number classification of enzymes. Isomerases can be further classified into six subclasses:
- EC 5.1 includes enzymes that catalyze racemization (racemases) and epimerization (epimerases)
- EC 5.2 includes enzymes that catalyze the isomerization of geometric isomers (cis-trans isomerases)
- EC 5.3 includes intramolecular oxidoreductases
- EC 5.4 includes intramolecular transferases (mutases)
- EC 5.5 includes intramolecular lyases
- EC 5.99 includes other isomerases (including topoisomerases)
[edit] References
- EC 5 Introduction from the Department of Chemistry at Queen Mary University of London
Active site - Binding site - Catalytically perfect enzyme - Coenzyme - Cofactor - EC number - Enzyme catalysis - Enzyme kinetics - Enzyme inhibitor - Lineweaver-Burk plot - Michaelis-Menten kinetics
EC1 Oxidoreductases,O+R+D/list (alcohol oxidoreductases, CH-CH oxidoreductases, peroxidase, oxygenase) - EC2 Transferases/list (methyltransferase, acyltransferase, glycosyltransferase, transaminase, phosphotransferase, polymerase, kinase) - EC3 Hydrolases/list (esterase, DNA glycosylases, glycosidase, protease, acid anhydride hydrolases) - EC4 Lyases/list (carboxy-lyases, aldolase, dehydratase, synthase, adenylate cyclase, guanylate cyclase) - EC5 Isomerases/list (mutase, topoisomerase) - EC6 Ligases/list (DNA ligase, aminoacyl tRNA synthetase)
