Kainic acid
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| Kainic acid | |
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| IUPAC name | 3-(carboxymethyl)-4-prop-1-en-2-yl- pyrrolidine-2-carboxylic acid |
| Other names | 2-Carboxy-3-carboxymethyl-4- isopropenyl-pyrrolidine |
| Identifiers | |
| CAS number | [] |
| PubChem | |
| SMILES | CC(=C)C1CNC(C1CC(=O)O)C(=O)O |
| Properties | |
| Molecular formula | C10H15NO4 |
| Molar mass | 213.2 g/mol |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
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Kainic acid is an acid present in some algae. It is similar to glutamate.
[edit] Occurrence
In 1953, kainic acid was originally isolated from the red alga called "Kainin-sou"(海人草) or "Makuri" (Digenea simplex) in Japan. "Kainin-sou" is used as an anthelmintic in Japan.
Kainic acid is a natural marine product originally isolated from the red marine alga D. simplex. It is a potent central nervous system stimulant, and has been developed as the prototype neuroexcitatory amino acid for the induction of seizures in experimental animals, at a typical dose of 10-30 mg/kg in mice. Kainic acid is neuroexcitotoxic and epileptogenic, acting through specific kainate receptors. Because of the supply shortage in 2000, the price of kainic acid has rised significantly. The current market price is about $3/mg (www.kainoids.com).
[edit] Applications of Kainic Acid
- antiworming agent
- neuroscience research
- neurodegenerative agent
- modeling of epilepsy
- modeling of Alzheimer's disease
[edit] See also
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