Lossen rearrangement
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The Lossen rearrangement is the chemical reaction of a hydroxamic acid 1 with a dehydration agent (such as tosyl chloride) to form the O-derivative 2, which spontaneously rearranges to form an isocyanate 3.
Several reviews have been published.
Hydroxamic acids are commonly synthesized from their corresponding esters.
[edit] References
- ↑ Lossen, W. Ann. 1872, 161, 347.
- ↑ Lossen, W. Ann. 1874, 175, 271 & 313.
- ↑ Yale, H. L. Chem. Rev. 1943, 33, 209. (Review)
- ↑ Bauer, L.; Exner, O. Angew. Chem. Int. Ed. Engl. 1974, 13, 376. (Review)
- ↑ Shiori, T. Comp. Org. Syn. 1991, 6, 821-825. (Review)
- ↑ Hauser, C. R.; Renfrow, Jr., W. B. Organic Syntheses, Coll. Vol. 2, p.67 (1943); Vol. 19, p.15 (1939). (Article)
[edit] See also
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