Mexiletine
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Mexiletine
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| Systematic (IUPAC) name | |
| 1-(2,6-dimethylphenoxy)propan-2-amine | |
| Identifiers | |
| CAS number | |
| ATC code | C01 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C11H17NO |
| Mol. mass | 179.259 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 90% |
| Protein binding | 50-60% |
| Metabolism | Hepatic (CYP2D6 and 1A2- mediated) |
| Half life | 10-12 hours |
| Excretion | Renal (10%) |
| Therapeutic considerations | |
| Pregnancy cat. | |
| Legal status | |
| Routes | Oral, IV |
Mexiletine (INN, sold under the trade name Mexitil®) belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.
Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by opening potassium channels.
Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002)
[edit] External links
[edit] References
- Peck T; Hill S, Williams M (eds.) (2004). Pharmacology for Anaesthesia and Intensive Care, 2nd ed., Cambridge University Press. ISBN 0-521-68794-2.
- Sweetman S (ed.) (2002). Martindale: The complete drug reference, 33rd ed., London: Pharmaceutical Press. ISBN 0-85369-499-0.
| Antiarrhythmic agents (C01B) | |
|---|---|
| class Ia | Ajmaline, Disopyramide, Prajmaline, Procainamide, Quinidine, Sparteine |
| class Ib | Aprindine, Lidocaine, Mexiletine, Tocainide |
| class Ic | Encainide, Flecainide, Lorcainide, Moricizine, Propafenone |
| class II | Propranolol, Metoprolol, Nadolol, Atenolol, Acebutolol, Pindolol see Beta blockers (C07) |
| class III | Amiodarone, Bretylium tosylate, Bunaftine, Dofetilide, Ibutilide, Sotalol |
| class IV | Verapamil, Diltiazem see Calcium channel blockers (C08) |
| class V | Adenosine, Atropine, Digoxin |
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