Plummer-Vinson syndrome
From Wikipedia, the free encyclopedia
| ICD-10 | D50.1 |
|---|---|
| ICD-9 | 280.8 |
| DiseasesDB | 10134 |
| MedlinePlus | 001158 |
| eMedicine | med/3431 |
| MeSH | D011004 |
The Plummer-Vinson syndrome, also called Paterson-Kelly syndrome or sideropenic dysphagia is a disorder linked to severe, long-term iron deficiency anemia, which causes swallowing difficulty (dysphagia) due to web-like membranes of tissue growing in the throat (esophageal webs). The cause of Plummer-Vinson syndrome is unknown; however, genetic factors and nutritional deficiencies may play a role. Women are at higher risk than men, particularly in middle age. The disease is named after two Americans, the physician Henry Stanley Plummer, and the surgeon Porter Paisley Vinson. In these patients squamous cell carcinoma risk is increased.
Contents |
[edit] Symptoms
- Dysphagia (difficulty in swallowing)
- Pain
- Weakness
- Odynophagia
[edit] Signs and tests
Serial contrasted gastrointestinal radiography or upper gastrointestinal endoscopy may reveal the web in the esophagus. Blood tests used to diagnose anemia and/or iron deficiency are also employed.
The condition is associated with koilonychia, glossitis, cheilitis, and splenomegaly.
[edit] Treatment
Patients with Plummer-Vinson syndrome should receive iron supplementation in their diet. This may improve dysphagia and pain. If not, the web can be dilated during upper endoscopy to allow normal swallowing and passage of food.
[edit] Prognosis
Patients generally respond well to treatment.
[edit] Complications
There is risk of perforation of the esophagus with the use of dilators for treatment. Furthermore it is one of the risk factors for developing squamus cell carcinoma of the oesophagus.
[edit] Prevention
Good nutrition with adequate intake of iron may prevent this disorder.
[edit] Source
- Plummer-Vynson Syndrome. MedlinePlus Medical Encyclopedia. US Federal Government public domain. Update Date: 1/2/2003. By: Jenifer K. Lehrer, M.D., Department of Gastroenterology, Graduate Hospital, Philadelphia, PA. Review provided by VeriMed Healthcare Network.
