Stephen aldehyde synthesis
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Stephen aldehyde synthesis, a named reaction in chemistry, invented by Henry Stephen (OBE/MBE). This reaction involves the preparation of aldehydes (R-CHO) from nitriles (R-CN) using Tin(II) chloride (SnCl2), hydrochloric acid (HCl) and quenching the resulting iminium salt ([R-CH=NH2]+Cl-) with water (H2O) [1] .
Reaction scheme:
R-CN + HCl + SnCl2 → [R-CH=NH2]+Cl- + H2O → R-CHO
[edit] References
- ^ Stephen, H., A new synthesis of aldehydes, J. Chem. Soc., Trans., 1925, 127, 1874 — 1877. DOI:10.1039/CT9252701874
