Acenocoumarol


Acenocoumarol
Systematic (IUPAC) name
2-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-4H- chromen-4-one
Identifiers
CAS number	152-72-7
ATC code	B01AA07
PubChem	9052
Chemical data
Formula	C₁₉H₁₅N O₆
Mol. mass	353.326 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	Hepatic
Half life	8 to 11 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	?
Legal status	POM(UK)
Routes	Oral

Acenocoumarol is an anticoagulant that functions as a vitamin K antagonist (like warfarin).

It is a derivative of coumarin and is marketed under the brand names Sintrom and Sinthrome®.

[edit] External links

DDB 29202
Cesar J, García-Avello A, Navarro J, Herraez M (2004). "Aging and oral anticoagulant therapy using acenocoumarol.". Blood Coagul Fibrinolysis 15 (8): 673-6. PMID 15613922.
Lengyel M (2004). "Warfarin or acenocoumarol is better in the anticoagulant treatment of chronic atrial fibrillation?". Orv Hetil 145 (52): 2619-21. PMID 15724697.
Ufer M (2005). "Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol.". Clin Pharmacokinet 44 (12): 1227-46. PMID 16372822.
Montes R, Ruiz de Gaona E, Martínez-González M, Alberca I, Hermida J (2006). "The c.-1639G > A polymorphism of the VKORC1 gene is a major determinant of the response to acenocoumarol in anticoagulated patients.". Br J Haematol 133 (2): 183-7. PMID 16611310.

v • d • e Antithrombotics (thrombolytics, anticoagulants, and antiplatelet drugs) (B01)
Vitamin K antagonists	Acenocoumarol, Clorindione, Dicumarol (Dicoumarol), Diphenadione, Ethyl biscoumacetate, Phenprocoumon, Phenindione, Tioclomarol, Warfarin
Heparin group (Platelet aggregation inhibitors)	Antithrombin III, Bemiparin, Dalteparin, Danaparoid, Enoxaparin, Heparin, Nadroparin, Parnaparin, Reviparin, Sulodexide, Tinzaparin
Other platelet aggregation inhibitors	Abciximab, Acetylsalicylic acid (Aspirin), Aloxiprin, Beraprost, Ditazole, Carbasalate calcium, Cloricromen, Clopidogrel, Dipyridamole,Eptifibatide, Indobufen, Iloprost, Picotamide, Prasugrel,Prostacyclin, Ticlopidine, Tirofiban, Treprostinil, Triflusal
Enzymes	Alteplase, Ancrod, Anistreplase, Brinase, Drotrecogin alfa, Fibrinolysin, Protein C, Reteplase, Saruplase, Streptokinase, Tenecteplase, Urokinase
Direct thrombin inhibitors	Argatroban, Bivalirudin,Dabigatran, Desirudin, Hirudin, Lepirudin, Melagatran, Ximelagatran
Other antithrombotics	Defibrotide, Dermatan sulfate, Fondaparinux, Rivaroxaban
Non-medicinal	Citrate, EDTA, Oxalate

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