Acepromazine
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Acepromazine
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| Systematic (IUPAC) name | |
| 1-{10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethanone | |
| Identifiers | |
| CAS number | |
| ATC code | N05 |
| PubChem | |
| Chemical data | |
| Formula | C19H22N2OS |
| Mol. mass | 326.457 |
| Pharmacokinetic data | |
| Bioavailability | 6.6L/kg, high volume of distribution |
| Metabolism | ? |
| Half life | 3 hours in horses |
| Excretion | found in equine urine up to 96 hours after dosage |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status |
not approved for use in cattle |
| Routes | IV, IM |
Acepromazine or Acetylpromazine (More commonly known as ACP, or by the trade name Atravet or "Acezine 2" etc, number depending on mg/ml dose) is one of the phenothiazine derivative psychotropic drugs, used little in humans, however frequently in animals as a sedative and antiemetic. Its principal value is in quietening and calming frightened and aggressive animals. The standard pharmaceutical preparation, acepromazine maleate, is used extensively in equine, feline, and canine; especially as a pre-anesthetic agent often in conjunction with Atropine, and often an opiate such as morphine or buprenorphine. Its depressive cardiopulmonary effects can be profound and as such is not recommended for use in geriatric or debilitated animals, (often substitued with Midazolam in these cases, or left out of the premed cocktail all together). ACP should not be used in sighthounds.
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