Alpha 2-antiplasmin
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| Identifiers | |
| Symbol | SERPINF2 PLI |
| HUGO | 9075 |
| Entrez | 5345 |
| OMIM | 262850 |
| RefSeq | NM_000934 |
| UniProt | P08697 |
| Other data | |
| Locus | Chr. 17 pter-p12 |
Alpha 2-antiplasmin (or α2-antiplasmin or plasmin inhibitor) is a serine protease inhibitor (serpin) responsible for inactivating plasmin, an important enzyme that participates in fibrinolysis and degradation of various other proteins.
The gene for A2AP is located on the short arm of the 17th chromosome (17pter-p12).
[edit] Role in disease
Very few cases (<20) of A2AP deficiency have been described. As plasmin degrades blood clots, impaired inhibition of plasmin leads to a bleeding tendency, which was severe in the cases reported.
[edit] External links
Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-antiplasmin - Antithrombin - C1-inhibitor - Heat shock protein 47 - Heparin cofactor II - Protein C inhibitor - Plasminogen activator inhibitor-1 - Plasminogen activator inhibitor-2 - Protein Z-related protease inhibitor
noninhibitory: Maspin - Ovalbumin - Thyroxine-binding globulin - Transcortin
Alpha 1-antichymotrypsin - Alpha 1-antitrypsin - Alpha 2-macroglobulin - Alpha 2-antiplasmin - Antithrombin - Ceruloplasmin - Haptoglobin - Heparin cofactor II - Orosomucoid - Retinol binding protein - Transcortin
