Ankyrin

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Ribbon diagram of a fragment of the membrane-binding domain of ankyrin 1. From PDB 1N11.
ankyrin 1, erythrocytic
Identifiers
Symbol	ANK1 ANK
HUGO	492
Entrez	286
OMIM	182900
RefSeq	NM_000037
UniProt	P16157
Other data
Locus	Chr. 8 p21.1-11.2

ankyrin 2, neuronal
Identifiers
Symbol	ANK2 LQT4
HUGO	493
Entrez	287
OMIM	106410
RefSeq	NM_001148
UniProt	Q01484
Other data
Locus	Chr. 4 q25-q27

ankyrin 3, node of Ranvier (ankyrin G)
Identifiers
Symbol	ANK3
HUGO	494
Entrez	288
OMIM	600465
RefSeq	NM_020987
UniProt	Q12955
Other data
Locus	Chr. 10 q21

Ankyrin is a membrane protein that mediates the attachment of the erythrocyte membrane skeleton to the plasma membrane and interacts with CD44 and inositol triphosphate.^[1]

Ankyrin contains three functional domains: a conserved N-terminal ankyrin repeat domain (ARD(consisting of 22–24 tandem repeats of 33 amino acids), a spectrin binding domain and a variably sized C-terminal regulatory domain.

[edit] References

1. ^ Singleton PA, Bourguignon LY. CD44 interaction with ankyrin and IP3 receptor in lipid rafts promotes hyaluronan-mediated Ca2+ signaling leading to nitric oxide production and endothelial cell adhesion and proliferation. Exp Cell Res. 2004 Apr 15;295(1):102-18.

[edit] External links

• MeSH Ankyrins