Talk:Antisense therapy
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Regarding the statement: This synthesized DNA is termed "anti-sense" DNA because its base sequence is the opposite of the gene's messenger RNA (so that a segment "AAGGTC" would be blocked by the anti-sense segment "TTCCAG"). These potential therapies have not yet produced significant clinical results.
Since the convention is to write any single nucleic acid strand in 5' to 3' orientation, the segment "AAGGTC" is not complementary to the segment "TTCCAG". Instead, the complement of "AAGGTC" is "GACCTT". It is acceptable to write a single strand in 3' to 5' orientation if it is clearly marked, so I have added orientation marks: "5'-AAGGTC-3'" and "3'-TTCCAG-5'". Keeping the second strand antiparallel with the first strand may make this more understandable to those unused to reading sense and antisense in opposite directions when looking for complementarity.
[edit] Merge
I support the merge. ViridaeTalk 07:01, 22 August 2006 (UTC)
- As no-one objected, I've merged with Antisense drugs. I've attempted to meld the two wordings, but this isn't my area of expertise so if I've made mistakes please correct them! Espresso Addict 03:32, 26 August 2006 (UTC)
