User talk:Banjotime
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Dear Banjotime:
Thanks so much for wikifying and adding to the paternal age page. There are many more disorders attributed/correlated to advancing paternal age than you listed and I think they or more of them should be included.
One source is this chart from J.J. Tarin et. al. 1999
Table II. Long-term effects of paternal ageing on offspring from table on page 2373 of Long –term effects of delayed parenthood by J.J. Tarin, J. Brines, and A. Cano
Dominant disorders Wilms tumour, thanatophoric dysplasia, retinitis pigmentosa, osteogenisis imperfecta type IIA, acrodysostosis, achondroplasia, Apert’s disease, fibrodysplasia ossificans progressiva, aniridia, bilateral retinoblastoma, multiple exostoses, Marfan’s, Lesch-Nyan’s, Pfeiffer’s, Wardenburg’s, Treacher-Collins, Soto’s, and Crouzon’s syndromes, basel cell nevus, cleidocranial dysostosis, polyposis coli, oculodentodigital syndrome, Costello syndrome , progeria, Recklinghausen’s neurofibromatosis, tuberous sclerosis and renal polycystic kidney disease.
X-linked recessive diseases Haemophilia A and Duchenne’s muscular dystrophy
Non-cytogenetic congential defects Congential cataracts, reduction defects of the upper limb, nasal aplasia, pulmonic and urethtal stenosis, perauricular cyst, cleft palate,1 neural tube defects
Athetoid /dystonic cerebral palsy and congenital hemiplegia
Psychotic disorders
Decreased learning capacity and/or mental retardation
Or one can go by the American College of Medical Genetics which is due to update its page very soon, probably before May. They will include the complex disorders of autism and schizophrenia. http://www.acmg.net/resources/policies/pol-016.asp
FROM 1996
There is no clear accepted definition of advanced paternal age. A frequently used criterion is any male, age 40 years or older at the time of conception, as opposed to the current population mean paternal age of 27 years. The risk for genetic defects does not increase dramatically at age 40, but rather increases linearly with age. Some studies have suggested that the risk of genetic defects, specifically, sporadic dominant single-gene mutations, is 4-5 times greater for fathers aged 45 and above than for their 20-25 year old counterparts.
Advanced paternal age is associated with an increased risk of new mutations. All populations are at risk. The relative increased risk for these defects is related to advanced age of the father for autosomal dominant conditions and the maternal grandfather for X-linked conditions. Family histories will not provide clues as these types of mutations are sporadic. Examples of autosomal dominant conditions associated with advanced paternal age include achondroplasia, neurofibromatosis, Marfan syndrome, Treacher Collins syndrome, Waardenberg syndrome, thanatophoric dysplasia, osteogenesis imperfecta, and Apert syndrome Examples of X-linked conditions associated with increased maternal grandfather's age include fragile X, hemophilia A (Factor VIII deficiency), Hemophilia B (Factor IX deficiency), Duchenne muscular dystrophy, incontinentia pigment), Hunter syndrome, Bruton agammaglobulinemia, and retinitis pigmentosa.
Given the wide range of genetic diseases which may be related to advanced paternal age, there is currently no single test available for prenatal screening or diagnosis. Unfortunately, prenatal ultrasound is not particularly useful in detecting many of these conditions. The detectable features may be nonspecific and could represent a variety of etiologies, not necessarily those related to advanced paternal age For this reason, screening ultrasounds specifically for advanced paternal age are usually of little benefit. Prospective couples should receive individualized genetic counseling to address specific concerns.
References:
Bishop, MWH, Walton A. Spermatogenesis and the structure of mammalian spermatozoa. In Marshall's Physiology of Reproduction 1:2, Edited by AS Parks. London, Longman, 1956, pl
Cohen FL. Paternal contributions to birth defects. Nurs Clin North Am 21:1, 1986
Friedman JM. Genetic disease in the offspring of older fathers. Obstet Gynecol 57:745, 1981
Hook EB. A search for a paternal-age effect upon cases of 47, +21 in which the extra chromosome is of paternal origin. Am J Hum Genet 36:413, 1984
Lian X-H, Zack MM, Erickson JD. Paternal age and the occurrence of birth defects. Am J Hum Genet 39:648, 1986
McKusick VA. Mendelian Inheritance in Man. Baltimore, The Johns Hopkins University Press, 1978
Murdoch JL, Walker BA, Hall JC, Abbey H, Smith KK, McKusick VA. Anchondroplasia-A Genetic and statistical survey. Ann Hum Genet 33:227, 1970
Morch ET. Chondrodystrophic dwarfs in Denmark. Opera ex Domo Biol Hered Hum Univ Hafn Vol 3 Munksguard, Kopenhagen, 1941
Penrose LS. Parental age and mutation. Lancet 2:312, 1955
Risch N, Reich EW, Wishnick MM, McCarthy JC. Spontaneous mutation and parental age in humans. Am J Hum Genet 41:218, 1987
Vogel R, Rathenberg R. Spontaneous mutation in man. Adv Hum Genet 5:223, 1975
Weinberg W. Zur Verebung des Zwergwuchses. Arch Rass Ges Biol 9:710. 1912
This guideline is designed primarily as an educational resource for medical geneticists and other health care providers to help them provide quality medical genetic services. Adherence to this guideline does not necessarily assure a successful medical outcome. This guideline should not be considered inclusive of all proper procedures and tests or exclusive of other procedures and tests that are reasonably directed to obtaining the same results. In determining the propriety of any specific procedure or test, the geneticist should apply his or her own professional judgment to the specific clinical circumstances presented by the individual patient or specimen. It may be prudent, however, to document in the patient's record the rationale for any significant deviation from this guideline.
Copyrighted by the American College of Medical Genetics, 1996
© 2001-2006 American College of Medical Genetics. All rights reserved
Please let me know what you think about adding this material. I do not want to do it myself.
Thanks,
Anniepema
Dear Annie,
Why don't you want to add it? I just happened to throw in a few sentences on what I had been reading online at the time. I was surprised there wasn't more info about it here! Statistically, paternal age matters more overall than maternal age in terms of genetic disorders. I wonder why that view is never at the fore? It's probably because of the lovely, subtley misogynistic culture in which we live; a culture that would prefer to listen to those evolutionary psychologist quacks justify men's own right to feeling like women can be treated as chattel.
Anyway, why don't you want to edit it?
