Certolizumab pegol
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Certolizumab pegol (CDP870) is a PEGylated Fab' fragment of a humanized anti-TNF-alpha monoclonal antibody. It is the subject of phase III clinical trials in both Crohn's disease and rheumatoid arthritis. Significant positive results have been demonstrated for two pivotal phase III trials (PRECiSE 1 and 2) of certolizumab pegol in moderate to severe active Crohn's disease. In addition, data from both trials suggest it is well-tolerated.
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