Clobetasol propionate
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Clobetasol propionate
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| Systematic (IUPAC) name | |
| [17-(2-chloroacetyl)- 9-fluoro-11-hydroxy-10,13,16-trimethyl- 3-oxo-6,7,8,11,12,14,15, 16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate | |
| Identifiers | |
| CAS number | |
| ATC code | D07 |
| PubChem | |
| DrugBank | |
| Chemical data | |
| Formula | C25H32ClFO5 |
| Mol. mass | 466.97 g/mol |
| Pharmacokinetic data | |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations | |
| Pregnancy cat. |
? |
| Legal status | |
| Routes | ? |
Clobetasol propionate comes in ointment and emollient cream presentations. It is a very high potency topical corticosteroid that should not be used with occlusive dressings. It is recommended that treatment should be limited to 2 consecutive weeks and therapy should be discontinued when adequate results have been achieved. Clobetasol propionate is marketed and sold worldwide under numerous names including Temovate (US), Tenovate, Dermovate, Dermatovate, and Butavate.
It is used to treat diseases such as eczema and psoriasis, where it is used on the scalp and body. Also dispensed to counter auto-immune presentations, such as Alopecia areata (hair loss due to auto-immune diseases).
[edit] Presentations
- Clobetasol propionate ointment USP 0.05%, supplied in 15 g, 30 g, 45 g, and 60 g tubes.
- Temovate & emollient 0.05%, supplied in 15 g (NDC 0173-0454-01), 30 g (NDC 0173-0454-02) and 60 g (NDC 0173-0454-03) tubes.
- Clobetasol propionate foam 0.05%
- Clobetasol propionate cream 0.05%
- Clobetasol propionate gel 0.05%
[edit] Possible side effects
- Acneform eruptions
- Allergic contact dermatitis
- Burning sensation
- Cracking and fissuring
- Cushing's syndrome
- Dryness
- Erythema
- Folliculitis
- Hypertrichosis
- Hypopigmentation
- Itching
- Irritation
- Millaria
- Numbness of fingers
- Perioral dermatitis
- Pruritus
- Secondary infection
- Skin atrophy
- Skin maceration
- Stinging
- Striae
- Telangiectasia
(A07EA, C05AA, D07, D10AA, H02, R01AD, R03BA, S01BA, S02B, and S03B)
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