Cryogenine
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Cryogenine, also known as vertine or (10α)-4,5-dimethoxy-2-hydroxylythran-12-one, is a biphenylquinolizidine lactone alkaloid from Heimia salicifolia and Heimia myrtifolia. It has anticholinergic properties and produces mild euphoria as well as aching of the muscles when taken in large doses.
The freebase form melts at 250-251 °C and is soluble in moderatly polar organic solvents such as chloroform, methylene chloride, benzene, and methanol, but is insoluble in water and petroleum ether.
In the development of thin layer chromatography plates with diazotized p-nitroaniline spray, vertine produces a purple spot (as does sinicuichine, another biphenylquinolizidine lactone alkaloid found in the Heimias).
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