CYP2E1

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Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.14.1), a member of the cytochrome P450 mixed-function oxidase system, is involved in the metabolism of xenobiotics in the body. While it is involved only in the oxidative metabolism of a small range of substrates (mostly small polar molecules), there are some important drug interactions mediated by CYP2E1.

[edit] CYP2E1 Ligands

Selected inducers, inhibitors and substrates of CYP2E11
Type	Agent
inducers	acetone, ethanol, isoniazid
inhibitors	cimetidine, disulfiram, (isoniazid)?
substrates	anaesthetics (halothane, isoflurane, etc), dapsone, paracetamol (acetaminophen), theophylline
Notes: Where classes of agents are listed, there may be exceptions within the class.

cytochrome P450, family 2, subfamily E, polypeptide 1
Identifiers
Symbol	CYP2E1 CYP2E
HUGO	2631
Entrez	1571
OMIM	124040
RefSeq	NM_000773
UniProt	P05181
Other data
Locus	Chr. 10 q24.3-qter

[edit] See also

• cytochrome
• metabolism