Talk:Cyproterone
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Anyone offering to convert hyperlinked PubMed abstracts to actual references? JFW | T@lk 16:40, 22 May 2006 (UTC)
[edit] hot flush vs hot flash
Hot flash menopause gets 1.6 million google hits while hot flush menopause gets only 0.45 million. I vote for hot flash as preferable but if this is one of those British vs American differences, nolo contendere. alteripse 00:47, 4 July 2006 (UTC)
- Possible so (I certainly have never heard it referred to as hot flash in the UK), the current article therefore seems to be from UK naming (with hot flash redirected to it). PubMed scientific search shows less distinction between use of terms with 959 for 'hot flash' and a slightly higher 989 for 'hot flush' :-) David Ruben Talk 10:01, 4 July 2006 (UTC)
[edit] "Acetate" confusion
The article says cyproterone acetate in the first line, but then makes reference to the acetate form as somehow something seperate from cyproterone acetate - can we make a clear distinction between cyproterone and cyproterone acetate and move this page to Cyproterone acetate if necessary? Yelyos 22:01, 6 August 2006 (UTC)
- Good point. Most steroid esters (eg acetate) are prodrugs which are metabolized to their active form by hydrolysis. Many sources seem to assume this and use the the terms cyproterone acetate and cyproterone interchangably. The statement about the progestational activity being due to the acetate form was in the intital article written by User:Jfdwolff. I can't find any sources to support the idea that there is any biological activity attributable specifically to the acetate form, so I think this statement should be removed. -- Kiral 08:09, 17 August 2006 (UTC)
- After further investigation, it does seem that many sources attribute pharmacological activity to the acetate form, although there is some conflicting information on this. I've added a section under pharmacology to explain this. If anyone has specific information on what effects are attributable to cyproterone rather than its acetate, please do share. -- Kiral 13:05, 30 August 2006 (UTC)
