Talk:Cytokine storm

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Article Grading: The following comments were left by the quality and importance raters: (edit · refresh) Would selective anti-T-cell medications be useful in the treatment of cytokine storm (ex : tacrolimus ?) ?

Contents 1 SIRS 2 QUESTION : 3 Cytokines & Cells Online Pathfinder Encyclopaedia 4 Cytokines and H5N1

[edit] SIRS

Irwin and Rippe's Intensive Care Medicine doesn't describe this as SIRS. Can anyone validate the claim this is correct? And if this turns out to be true, shouldn't the articles be merged? Nomen Nescio^{Gnothi seauton} 19:19, 29 May 2006 (UTC)

It is not the same, to quote the NEJM:

"Proposed Mechanism of the Cytokine Storm Evoked by Influenzavirus. The key element in generating the storm is an uncontrolled exuberant immune response to the virus, in which there is an outpouring of proinflammatory cytokines and chemoattractants."[1]

Since SIRS by definition is a condition in which infection is absent, this proves SIRS and cytokine storm are NOT the same. In other words, the storm may be part of SIRS, but is not limited to SIRS. Nomen Nescio^{Gnothi seauton} 19:43, 29 May 2006 (UTC)

Cecil's Textbook of medicine (21st edition, year: 2000, Goldman and Bennett, eds.) does not list any reference to "cytokine storm". The first reference in Pub Med appears to be by Ferrara in GVHD, and was published in Feb 1993.

I agree that Cytokine storm and SIRS are indeed not synomous, and that the 2 should be kept as separate topics. Cytokine Storm is not a disease, but a feature of many diseases, both infectious (SEPSIS, avian flu) and non-infectious (i.e. GVHD and SIRS) 23:50, May 30, 2006, User:Petrosino.

[edit] QUESTION :

Would selective anti-T-cell medications be useful in the treatment of cytokine storm (ex : tacrolimus ?) ?

Retrieved from "http://en.wikipedia.org/wiki/Talk:Cytokine_storm/Comments"

[edit] Cytokines & Cells Online Pathfinder Encyclopaedia

Although a very interesting site, this is not a medical reference. Please provide a medical journal or textbook. Second, you fail to understand that severe infection also causes a "cytokine storm." Since SIRS is defined as absence of infection how do you differentiate between infection and non-infection related "cytokine storm?" Analogy: apples are fruit, but fruit not necesseraly refers to apples. In short, the assertion is incorrect. Please amend accordingly. Nomen Nescio^{Gnothi seauton} 09:36, 30 May 2006 (UTC)

Like the current version. Explains the concept very good. Thank you. Nomen Nescio^{Gnothi seauton} 06:56, 31 May 2006 (UTC)

[edit] Cytokines and H5N1

BBC story on cytokine role in making H5N1 in humans deadly.