Benutzer:YourEyesOnly/Piperazin
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| Strukturformel | |
|---|---|
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| Allgemeines | |
| Name | Meclozin |
| Andere Namen | 1-[(4-chlorphenyl)-phenyl-methyl]-4-(3-methylphenyl)methyl]piperazine-1,4-Diethylendiamin |
| Summenformel | C25H27ClN2 |
| CAS-Nummer | 569-65-3 |
| Kurzbeschreibung | weißes Pulver mit bitter-salzigem Geschmack |
| Eigenschaften | |
| Molmasse | 390,948 g·mol-1 |
| Aggregatzustand | fest |
| Dichte | ? g·cm-3 |
| Schmelzpunkt | °C |
| Siedepunkt | °C |
| Dampfdruck | kPa (20 °C) |
| Löslichkeit | in Wasser gut, in Ether unlöslich |
| Sicherheitshinweise | |
| Vorlage:Gefahrensymbol 1 | |
| R- und S-Sätze | R: 34-42/43-52/53 S: ? |
| MAK | 0,1 mg/m3 (Langzeitwert) 0,3 mg/m3 (Kurzzeitwert) |
| Soweit möglich und gebräuchlich, werden SI-Einheiten verwendet. Wenn nicht anders vermerkt, gelten die angegebenen Daten bei Standardbedingungen. | |
Inhaltsverzeichnis |
[Bearbeiten] Geschichte
[Bearbeiten] Gewinnung und Darstellung
[Bearbeiten] Eigenschaften
[Bearbeiten] Verwendung
[Bearbeiten] Sicherheitshinweise
[Bearbeiten] Quellen
| image = meclizine_chemical_structure.jpeg
| ATC_prefix = A04 | ATC_suffix = AB04 | ATC_supplemental = R06AE05 | PubChem = 4034 | DrugBank = APRD00354 | molecular_weight = 390.948 g/mol | elimination_half-life = 6 hours | pregnancy_category = B
| routes_of_administration = Oral |Relief of nausea and motion sickness |-
|Contraindications |Alcohol; Clinical studies in children have not been done; usage is not recommended under 12 years of age. |- |Side effects |Drowsiness |- |} Meclizine (proposed INN is meclozine) is an antihistamine, considered to be an antiemetic. It is most commonly used to inhibit nausea and vomiting. An alternative to dimenhydrinates like Dramamine, Meclizine is considered to perform the same functions at an equitable level of effectiveness, but with reduced side effects.
[Bearbeiten] Uses
[Bearbeiten] Motion Sickness
Meclizine is effective in inhibiting the symptoms of motion sickness, such as nausea, vomiting, and dizziness.
[Bearbeiten] Vertigo
Meclizine may be effective in relieving vertigo experienced as a result of inner ear infections or other conditions.
[Bearbeiten] Risks of Use
[Bearbeiten] Drowsiness
Drowsiness may result as a side effect of taking Meclizine. While the effects are less than Dramamine, users are advised not to operate heavy machinery while under the influence. The consumption of alcohol while under the influence of Meclizine may result in additional drowsiness.
[Bearbeiten] Pregnancy
Studies have shown that cleft palates of fetuses were formed when pregnant rats were exposed to 25-50 times a normal dosage. Nevertheless, pregnant women are advised not to take Meclizine unless it is absolutely necessary.
[Bearbeiten] Anticholinergics
Due to its possible anticholinergic action, Meclizine should be used carefully with patients who suffer from asthma, glaucoma, or an enlarged prostate gland.
[Bearbeiten] Commercial Names
Meclizine hydrochloride is sold under the commercial names
- Dramamine II®
- Dramamine Less Drowsy®
- Antivert®
- Bonine®
- Bonamine®
- Bonikraft®
- Emetostop®
- Medivert®
- Sea-Legs®
[Bearbeiten] External links
- [1] – University of Berlin's Institute of Biochemistry
- [2] – Numark Pharmacies Information Page on Meclizine
- [3] Rxlist Medical Dictionary
