Emil du Bois-Reymond

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Emil Heinrich du Bois-Reymond.

Emil du Bois-Reymond (b. November 7, 1818, Berlin, Germany; d. December 26, 1896), was a German physician and physiologist, discoverer of the nerve action potential and the father of experimental electrophysiology.

[edit] Life

The Prussian capital was the place both of his birth and of his life's work, and he will always be counted among Germany's great scientists; yet he was not of German descent. His father originated from Neuchâtel, Switzerland, his mother was of French Huguenot descent, and he spoke of himself as "being of pure Celtic blood."

Educated first at the French College in Berlin, then at Neuchâtel, where his father had returned, he entered in 1836 the University of Berlin. He seems to have been uncertain at first as to the bent of his studies, for he sat at the feet of the great ecclesiastical historian August Neander, and dallied with geology; but eventually he threw himself into the study of medicine, with such zeal and success as to attract the notice of the great teacher of anatomy and physiology, who was then making Berlin famous as a school for the sciences ancillary to medicine, Johannes Peter Müller (1801-1858).

Müller is rightly regarded as the central figure in the history of modern physiology, in the 19th century. His earlier studies had been distinctly physiological; but his inclination, no less than his position as professor of anatomy as well as of physiology in the University of Berlin, led him later on into wide studies of comparative anatomy, and these, aided by the natural bent of his mind towards problems of general philosophy, gave his views of physiology a breadth and a depth which profoundly influenced the progress of that science in his day. He had, about the time when the young Du Bois-Reymond came to his lectures, published his great Elements of Physiology, the dominant note of which may be said to he this:

"Though there appears to be something in the phenomena of living beings which cannot be explained by ordinary mechanical, physical or chemical laws, much may be so explained, and we may without fear push these explanations as far as we can, so long as we keep to the solid ground of observation and experiment."

Müller recognized in the Neuchâtel had a mind fitted to carry on physical researches into the phenomena of living things in a legitimate way. He made him in 1840 his assistant in physiology, and as a starting-point for an inquiry put into his hands the essay which the Italian Carlo Matteucci, had just published on the electric phenomena of animals. This determined the work of Du Bois-Reymond's life. He chose as the subject of his graduation thesis "Electric fishes," and so commenced a long series of investigations on bioelectricity, by which he enriched science and made for himself a name. The results of these inquiries were made known partly in papers communicated to scientific journals, but also and chiefly in his work Researches on Animal Electricity, the, first part of which appeared in 1848, the last in 1884.

[edit] Works

Du Bois-Reymond's great work may be regarded under two aspects. On the one hand, it is a record of the exact determination and approximative analysis of the electric phenomena presented by living beings. Viewed from this standpoint, it represents a remarkable advance of our knowledge. Du Bois-Reymond, beginning with the imperfect observations of Matteucci, built up this branch of science. He did so by inventing or improving methods, by devising new instruments of observation or by adapting old ones. The debt which science owes to him on this score is a large one indeed.

On the other hand, the volumes in question contain an exposition of a theory. In them Du Bois-Reymond put forward a general conception by the help of which he strove to explain the phenomena which he had observed. He developed the view that a living tissue, such as muscle, might be regarded as composed of a number of "electric molecules", of molecules having certain electric properties, and that the electric behaviour of the muscle as a whole in varying circumstances was the outcome of the behaviour of these native electric molecules. We now know that these are the sodium, potassium and other ions which are responsible for electric membrane phenomena in excitable celles.

Emil du Bois-Reymond.

His theory was soon attacked by several contemporary physiologists, such as Ludimar Hermann, who maintained that a living untouched tissue, such as a muscle, is not the subject of electric currents so long as it is at rest, it is isoelectric in substance, and therefore need not be supposed to be made up of electric molecules, all the electric phenomena which it manifests being due to internal molecular changes associated with activity or injury. Du Bois-Reymond's theory was of great value if only as a working hypothesis, and that as such it greatly helped in the advance of science. Thus, Du Bois-Reymond's work lay chiefly in the direction of animal electricity, yet he carried his inquiries--such as could be studied by physical methods--into other parts of physiology, more especially into the phenomena of diffusion, though he published little or nothing concerning the results at which he arrived.

For many years, too, he exerted a great influence as a teacher. In 1858, upon the death of Johannes Müller, the chair of anatomy and physiology, which that great man had held, was divided into a chair of human and comparative anatomy, which was given to Karl Bogislaus Reichert (1811-1883), and a chair of physiology, which naturally fell to Du Bois-Reymond. This he held to his death, carrying out his researches for many years under unfavourable conditions of inadequate accommodation. In 1877, through his influence, the government provided the university with a proper physiological laboratory. In 1851 he was admitted into the Academy of Sciences of Berlin, and in 1867 became its perpetual secretary.

For many years he and his friend Hermann von Helmholtz, who like him had been a pupil of Johannes Peter Müller, were prominent scientists and professors in the German capital. Acceptable at court, they both used their position and their influence for the advancement of science. Both, from time to time as opportunity offered, stepped out of the narrow limits of the professorial chair and gave the world their thoughts concerning things on which they could not well dwell in the lecture room. Du Bois-Reymond, as has been said, had in his earlier years wandered into fields other than those of physiology and medicine, and in his later years he went back to some of these. His occasional discourses, dealing with general topics and various problems of philosophy, show that to the end he possessed the historic spirit which had led him as a lad to listen to Neander; they are marked not only by a charm of style, but by a breadth of view such as might be expected from Johannes Müller's pupil and friend.

He is now remembered also in terms of the ignorabimus, to which he gave common currency. The mathematician Paul David Gustav du Bois-Reymond (1831-1889) was his brother.}