Endogenous mediator
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Endogenous mediators are intracellular proteins that enhance and activate other proteins.
The term "endogenous mediator" is commonly used in molecular biology and cell biology. The mediator is located within the cell nucleus. There are different types of mediators depending on where in the cell it exists and exert its effects, but generally the mediator's main quality is to enhance the activity of their helping proteins (see below).
On the molecular level, the mediator is required for the successful transcription of nearly all class II gene promoters in yeast. It works in the same manner in mammals. The mediator functions as a coactivator and binds to the C-terminal domain (CTD) of RNAPII holoenzyme, which transcribes/makes most of the RNA (mRNA) in the cell -which at a later stage becomes translated to a protein.
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