Talk:Estrogen receptor

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There's a review in this week's JCI detailing the role of the ER in disease. Possibly useful: Deroo BJ, Korach KS. Estrogen receptors and human disease. J Clin Invest 2006;116:561-70. PMID 16511588. JFW | T@lk 22:58, 9 March 2006 (UTC)

[edit] Image

I just wanted to point out that the picture labeled "an estrogen receptor dimer" is actually a dimer of the Ligand binding domain of Estrogen Receptor. No one has yet to be able to crystalize the whole protien, because the hinge region is so flexible. The two crystal structures I seen for ER are the Ligand binding domain dimer (shown here) and the DNA binding domain dimer.

Thank you! JFW | T@lk 03:46, 17 March 2006 (UTC)

[edit] domain structure

"AF1 / Growth Hormone binding"

Can anyone provide a reference that explains the relationship between AF1 and growth hormone?--JWSchmidt 20:11, 13 June 2006 (UTC)

[edit] signal transduction

Are not ERs type I nuclear receptors that exist in cytosol prior to estrogen binding and enter the cell nucleus as a hormone-receptor complex after the hormone is bound? The current page indicates othewise. 129.81.97.247 04:08, 29 March 2007 (UTC)