Exonuclease
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[edit] Introduction
Exonucleases which can be found as individual enzymes, or as parts of larger enzyme complexes, are enzymes that cleave nucleotides one at a time from an end of a polynucleotide chain. These enzymes hydrolyze phosphodiester bonds from either the 3' or 5' terminus of polynucleotide molecules.
[edit] Examples
DNA polymerase I contains a 5' exonuclease that chips off the RNA primer contained immediately upstream from the site of DNA synthesis in a 3' --> 5' manner. It then allows Pol I to synthesize DNA nucleotides in place of the RNA primer it had just erased.
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Endonuclease (Restriction enzyme) - Exonuclease - Ribonuclease - RNase H - Deoxyribonuclease - Micrococcal nuclease
