Angioplasty

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Angioplasty is the mechanical widening of a narrowed or totally-obstructed blood vessel. These obstructions are often caused by atherosclerosis.

The term "angioplasty" is a portmanteau of the words "angio" (from the Latin/Greek word meaning vessel) and "plasticos" (Greek: fit for molding). Angioplasty has come to include all manner of vascular interventions typically performed in a minimally-invasive or "percutaneous" method.

[edit] Coronary angioplasty

A coronary angiogram (an X-ray with radio-opaque contrast in the coronary arteries) that shows the left coronary circulation. The distal left main coronary artery (LMCA) is in the left upper quadrant of the image. Its main branches (also visible) are the left circumflex artery (LCX), which courses top-to-bottom initially and then toward the centre/bottom, and the left anterior descending (LAD) artery, which courses from left-to-right on the image and then courses down the middle of the image to project underneath of the distal LCX. The LAD, as is usual, has two large diagonal branches, which arise at the centre-top of the image and course toward the centre/right of the image.

Main article: Percutaneous coronary intervention

Coronary angioplasty, also known as "percutaneous transluminal coronary angioplasty", was first developed in 1977 by Andreas Gruentzig. The procedure was quickly adopted by numerous cardiologists, and by the mid-1980's, many leading medical centers throughout the world were adopting the procedure as a method to avoid bypass surgery.

Angioplasty is sometimes eponymously referred to as Dottering, after Dr Charles Theodore Dotter, who, together with Dr Melvin P. Judkins, first described angioplasty in 1964^[1]. As the range of procedures performed upon lumens of coronary arteries has widened, the name of the procedure has changed to percutaneous coronary intervention (PCI).

Sometimes a small mesh tube, or "stent", is introduced into the blood vessel or artery to prop it open using percutaneous methods. Angioplasty with stenting is a viable alternative to heart surgery.^[2] It has consistently been shown to reduce symptoms due to coronary artery disease and to reduce cardiac ischemia, but has not been shown in large trials to reduce mortality due to coronary artery disease, except in patients being treated for a heart attack acutely (also called primary angioplasty). There is a small but definite reduction of mortality with this form of treatment compared with medical therapy, which usually consists of the administration of thrombolytic ("clot busting") medication.^[3][4]

[edit] Procedure

The angioplasty procedure usually consists of most of the following steps:

1. Access into the femoral artery in the leg (or, less commonly, into the radial artery or brachial artery in the arm) is created by a device called an "introducer needle". This procedure is often termed percutaneous access.
2. Once access into the artery is gained, a "sheath introducer" is placed in the opening to keep the artery open and control bleeding.
3. Through this sheath, a long, flexible, soft plastic tube called a "guiding catheter" is pushed. The tip of the guiding catheter is placed at the mouth of the coronary artery. The guiding catheter also allows for radiopaque dyes (usually iodine based) to be injected into the coronary artery, so that the disease state and location can be readily assessed using real time x-ray visualization.
4. During the x-ray visualization, the cardiologist estimates the size of the coronary artery and selects the type of balloon catheter and coronary guidewire that will be used during the case. Heparin (a "blood thinner" or medicine used to prevent the formation of clots) is given to maintain blood flow.
5. The coronary guidewire which is an extremely thin wire with a radiopauqe flexible tip that is inserted into through the guiding catheter and into the coronary artery. While visualizing again by real-time x-ray imaging, the cardiologist guides the wire through the coronary artery to the site of the stenosis or blockage. The tip of the wire is then passed across the blockage. The cardiologist controls the movement and direction of the guide wire by gently manipulating the end that sits outside the patient through twisting of the guidewire.
6. While the guidewire is in place, it now acts as the pathway to the stenosis. The tip of the angioplasty or balloon catheter is hollow and is then inserted at the back of the guidewire--thus the guidewire is now inside of the angioplasty catheter. The angioplasty catheter is gently pushed forward, until the deflated balloon is inside of the blockage.
7. The balloon is then inflated, and it compresses the atheromatous plaque and stretches the artery wall to expand.
8. If an expandable wire mesh tube (stent) was on the balloon, then the stent will be implanted (left behind) to support the new stretched open position of the artery from the inside.^[5]

[edit] Coronary stenting

Traditional ("bare metal") coronary stents provide a mechanical framework that holds the artery wall open, preventing stenosis, or narrowing, of coronary arteries. PTCA with stenting has been shown to be superior to angioplasty alone in patient outcome by keeping arteries patent for a longer period of time.^[6]

Newer drug-eluting stents (DES) are traditional stents that are coated with drugs, which, when placed in the artery, release certain drugs over time. It has been shown that these types of stents help prevent restenosis of the artery through several different physiological mechanism, most of which rely upon the suppression of tissue growth at the stent site. Three drugs, sirolimus, everolimus and paclitaxel, have been demonstrated safety and efficacy in this application in controlled clinical trials by stent device manufacturers.^{[citation needed]} However, in 2006 three broad European trials seem to indicate that drug-eluting stents may be susceptible to an event known as "late stent thrombosis", where the blood-clotting inside the stent can occur one or more years post-stent. While this event is rare, it is extremely dangerous and is fatal in about one-third of cases when the thrombosis occurs. ^[7][8]

[edit] Risks

Risks of angioplasty are uncommon, and the procedure is widely practiced. Coronary angioplasty is usually performed by an interventional cardiologist, a medical doctor with special training in the treatment of the heart using invasive catheter-based procedures.^{[citation needed]}

Angioplasty has become considerably safer over the years and is now commonly performed. Although it is associated with some risks^[9] these are considerably less than for open-heart bypass surgery with its resulting post-operative pain. However the likelihood of recurrence of angina, and requirement for repeated procedures has been higher with angioplasty. The latest trial (ARTS II) has suggested that PCI with DES may be superior, at least in the short term.

Some chest discomfort occasionally may be experienced and it is for this reason that the patient is awake during minimally invasive angioplasty; the reporting of any symptom allows the cardiologist to take necessary immediate action. Bleeding from the insertion point in the groin is common, in part due to the use of anti-platelet clotting drugs. Some bruising is therefore to be expected, but occasionally a hematoma may form. This may delay hospital discharge as flow from the artery into the hematoma may continue (pseudoaneurysm) which requires repair. Infection at the skin puncture site is rare and dissection (tearing) of the access blood vessel is uncommon. Allergic reaction to the contrast dye used is possible, but has been reduced with the newer agents. Deterioration of kidney function can occur in patients with pre-existing kidney disease, but kidney failure requiring dialysis is rare. Vascular access complications are less common and less serious when the procedure is performed via the radial artery.

In the long term, the most common risk is of the stent restenosis, as discussed above. This has been reduced considerably with the use of newer stents coated with certain medicines (drug-eluting stents). The most serious risk is the rare provocation (3%) of a heart attack during or shortly after the procedure; this may require emergency open cardiac surgery. Angioplasty carried out shortly after a myocardial infarction has a risk of causing a stroke of 1 in 1000, which is less than the 1 in 100 risk encountered by those receiving thrombolytic drug therapy.

The overall risks of death with angioplasty is approximately 1%, but the underlying severity of the heart disease, fitness of the patient and presence of other illness affect each individual’s risk. Hence for those with relatively minor heart disease, preserved good cardiac function, reasonable level of fitness and absence of other illnesses, the risk will be considerably less.

When failures of PTCA occur, they are often treated using coronary artery bypass grafting (CABG).

[edit] Peripheral angioplasty

Peripheral angioplasty refers to the use of mechanical widening in opening blood vessels other than the coronary arteries. It is often called percutaneous transluminal angioplasty or PTA for short. PTA is most commonly done to treat narrowings in the leg arteries, especially the common iliac, external iliac, superficial femoral and popliteal arteries. PTA can also be done to treat narrowings in veins.

[edit] Renal artery angioplasty

Atherosclerotic obstruction of the renal artery can be treated with angioplasty of the renal artery (percutaneous transluminal renal angioplasty, PTRA). Renal artery stenosis can lead to hypertension and loss of renal function.

[edit] Carotid angioplasty

Generally, carotid artery stenosis is treated with angioplasty and stenting for high risk patients in many hospitals. It has changed since the FDA has approved the first carotid stent system (Cordis) in July 2004 and the second (Guidant) in August 2004. The system comprises a stent along with an embolic capture device designed to reduce or trap emboli and clot debris. Angioplasty and stenting is increasingly being used to also treat carotid stenosis, with success rates similar to carotid endarterectomy surgery. Simple angioplasty without stenting is falling out of favor in this vascular bed. SAPPHIRE, a large trial comparing carotid endarterectomy and carotid stenting with the Cordis stent found stenting non-inferior to carotid endarterectomy. ^[10].

[edit] See also

• Charles Dotter
• Coronary artery bypass surgery
• Cardiac Catheterization
• Cutting balloon

[edit] References

1. ^ Dotter, C. T. and M. P. Judkins, Transluminal Treatment of Arteriosclerotic Obstruction: Description of a New Technic and a Preliminary Report of Its Application, Circulation, 1964; 30:654-70.
2. ^ Michaels, A. D. and K. Chatterjee, Angioplasty Versus Bypass Surgery for Coronary Artery Disease, Circulation, 2002; 106:e187
3. ^ Mercado, N, Flather, MD, Boersna, E, et al, on Behalf of the Trial Investigators CABG vs Stenting for Multivessel Disease: a Meta-analysis of ARTS-1, SoS, ERACI-2, and MASS-2, Presentation at European Society of Cardiology Congress 2003
4. ^ W. D. Weaver, R. J. Simes, A. Betriu, C. L. Grines, F. Zijlstra, E. Garcia, L. Grinfeld, R. J. Gibbons, E. E. Ribeiro, M. A. DeWood and F. Ribichini Comparison of primary coronary angioplasty and intravenous thrombolytic therapy for acute myocardial infarction: a quantitative review, Journal of the American Medical Association 278:23, December 17, 1997.
5. ^ PTCA or Balloon Angioplasty
6. ^ MM Gandhi, and KD Dawkins Clinical review: Intracoronary stents BMJ 1999;318(7184):650 (6 March)
7. ^ L Mauri, W Hsieh, JM Massaro, KKL Ho, R D’Agostino, and DE Cutlip. Stent Thrombosis in Randomized Clinical Trials of Drug-Eluting Stents N Engl J Med 2007;356:1020-9.
8. ^ European Society of Cardiology Science News, 2007 Thrombosis is the price for the success of drug-eluting stents
9. ^ UK's NHS endorsed 'Best Treatments' advice on 'clinical evidence for patients from the BMJ' on Coronary angioplasty and its risks
10. ^ Yadav JS, Wholey MH, Kuntz RE, Fayad P, Katzen BT, Mishkel GJ, Bajwa TK, Whitlow P, Strickman NE, Jaff MR, Popma JJ, Snead DB, Cutlip DE, Firth BG, Ouriel K. Protected carotid-artery stenting versus endarterectomy in high-risk patients. N Engl J Med 2004;351:1493-501. PMID 15470212.

[edit] External links

• Angioplasty.Org
• Cardiovascular and Interventional Radiological Society of Europe
• Society for Cardiovascular Angiography and Interventions
• Cardiovillage, cardiovascular education online
• National Heart Lung and Blood Institute, Diseases and Conditions Index
• Overview Coronary Artery Disease Treatment - Coronary Interventions ANGIOPLASTY, STENTS AND ATHERECTOMY (Cleveland Clinic)