Bambuterol
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Bambuterol
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| Systematic (IUPAC) name | |
| {3-(dimethylcarbamoyloxy)-5-[1-hydroxy-2-(tert-butylamino) ethyl]phenyl} N,N-dimethylcarbamate |
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| Identifiers | |
| CAS number | |
| ATC code | R03 |
| PubChem | |
| Chemical data | |
| Formula | C18H29N3O5 |
| Mol. mass | 367.44 g/mol |
| Pharmacokinetic data | |
| Bioavailability | 20% |
| Metabolism | Hepatic, extensive Further metabolized to terbutaline by plasma cholinesterase |
| Half life | 13 hours (bambuterol) 21 hours (terbutaline) |
| Excretion | Renal |
| Therapeutic considerations | |
| Pregnancy cat. |
Unknown |
| Legal status |
℞ Prescription only |
| Routes | Oral |
Bambuterol (INN, marketed by AstraZeneca under the trade names Bambec® and Oxeol®) is a long acting beta-adrenoceptor agonist used in the treatment of asthma. It is a prodrug of terbutaline.
| Medications commonly used in asthma and COPD (primarily R03) | |
|---|---|
| Anticholinergics | Ipratropium, Tiotropium |
| Short acting β2-agonists | Salbutamol, Terbutaline |
| Long acting β2-agonists (LABA) | Bambuterol, Clenbuterol, Fenoterol, Formoterol, Salmeterol |
| Corticosteroids | Beclometasone, Budesonide, Ciclesonide, Fluticasone |
| Leukotriene antagonists | Montelukast, Pranlukast, Zafirlukast |
| Xanthines | Aminophylline, Theobromine, Theophylline |
| Mast cell stabilizers | Cromoglicate, Nedocromil |
| Combination products | Budesonide/formoterol, Fluticasone/salmeterol, Ipratropium/salbutamol |
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