Ground substance
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Ground substance is an extremely outdated term for the non-collagenous components of extracellular matrix, traditionally used only by retired scientists and lay people. Cells are surrounded by extracellular matrix in tissues, which acts as a support for the cells. Ground substance traditionally does not include collagen but does include all the other proteinaceous components, including proteoglycans, matrix proteins and water. The non-collagenous components of extracellular matrix will vary depending on the tissue where it is found.
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