H₂ receptor
From Wikipedia, the free encyclopedia
|
histamine receptor H2
|
|
| Identifiers | |
| Symbol | HRH2 |
| HUGO | 5183 |
| Entrez | 3274 |
| OMIM | 142703 |
| RefSeq | NM_022304 |
| UniProt | P25021 |
| Other data | |
| Locus | Chr. 5 q35 |
H2 receptors positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production. It increases the intracellular Ca2+ concentrations and release Ca2+ from intracellular stores.
The drug Betazole is an example of a Histamine H2 receptor agonist.
Contents |
[edit] Location
- Gastric parietal cells (oxyntic cells)
- Vascular smooth muscle
- Neutrophils
- Central nervous system
- Heart
- Uterus
[edit] Response
- Stimulation of gastric acid secretion
- Smooth muscle relaxation
- Inhibit antibody synthesis, T-cell proliferation and cytokine production
[edit] H2-receptor agonists and antagonists
see H2-receptor agonist and H2-receptor antagonist
[edit] External links
Adenosine - Adrenergic - Angiotensin - Bradykinin - Calcitonin - Cannabinoid - Chemokine - Cholecystokinin - Corticotropin-releasing hormone - Dopamine - Endothelin - FSH-receptor - GABA B - Galanin - Glucagon - Gonadotropin-releasing hormone - Histamine (H1, H2, H3, H4) - Luteinizing hormone/choriogonadotropin - Melanocortin (MC1R, MC2R) - Melatonin - Metabotropic glutamate - Muscarinic acetylcholine - Neurotensin - Olfactory - Opioid (Delta, Kappa, Mu, Sigma, Nociceptin) - Parathyroid hormone - Purinergics (P2Y) - Trace amine-associated - Secretin - Serotonin, all but 5-HT3 (5-HT2A)
