Inositol triphosphate receptor
From Wikipedia, the free encyclopedia
|
inositol 1,4,5-triphosphate receptor, type 1
|
|
| Identifiers | |
| Symbol | ITPR1 |
| HUGO | 6180 |
| Entrez | 3708 |
| OMIM | 147265 |
| RefSeq | NM_002222 |
| UniProt | Q14643 |
| Other data | |
| Locus | Chr. 3 p26.1 |
|
inositol 1,4,5-triphosphate receptor, type 2
|
|
| Identifiers | |
| Symbol | ITPR2 |
| HUGO | 6181 |
| Entrez | 3709 |
| OMIM | 600144 |
| RefSeq | NM_002223 |
| UniProt | Q14571 |
| Other data | |
| Locus | Chr. 12 p11.23 |
|
inositol 1,4,5-triphosphate receptor, type 3
|
|
| Identifiers | |
| Symbol | ITPR3 |
| HUGO | 6182 |
| Entrez | 3710 |
| OMIM | 147267 |
| RefSeq | NM_002224 |
| UniProt | Q14573 |
| Other data | |
| Locus | Chr. 6 p21.31 |
Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3).
Contents |
[edit] Distribution
It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.
[edit] Structure
The IP3R complex is formed of four 313 kDa subunits. There are 3 isoforms and these can form homo- or hetero-oligomers.
[edit] See also
- inositol
- inositol phosphate
- myo-inositol (inositol monophosphate).
- inositol triphosphate
- inositol pentakisphosphate
- inositol hexaphosphate
[edit] External links
 |
This protein-related article is a stub. You can help Wikipedia by expanding it. |
Stretch-activated ion channel - Ligand-gated ion channel - Voltage-gated ion channel
Ca: Voltage-dependent calcium channel (L-type/CACNA1C, N-type, P-type, Q-type, R-type, T-type) - Inositol triphosphate receptor - Ryanodine receptor - Cation channels of sperm
Na: Sodium channel: SCN4A - SCN5A - SCN9A - Epithelial sodium channel /Amiloride-sensitive sodium channel
K: Potassium channel: Voltage-gated (KvLQT1, HERG, Shaker gene, KCNE1) - Calcium-activated (BK channel, SK channel) - Inward-rectifier (ROMK, KCNJ2) - Tandem pore domain/Resting ion channel
Cl: Chloride channel: Cystic fibrosis transmembrane conductance regulator
Transient receptor potential (TRPV6) - Cyclic nucleotide-gated ion channel - Two-pore channel
