List of EC numbers (EC 6)
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This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.
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[edit] EC 6.1: Forming Carbon-Oxygen Bonds
[edit] EC 6.1.1: Ligases Forming Aminoacyl-tRNA and Related Compounds
- EC 6.1.1.1: tyrosine—tRNA ligase
- EC 6.1.1.2: tryptophan—tRNA ligase
- EC 6.1.1.3: threonine—tRNA ligase
- EC 6.1.1.4: leucine—tRNA ligase
- EC 6.1.1.5: isoleucine—tRNA ligase
- EC 6.1.1.6: lysine—tRNA ligase
- EC 6.1.1.7: alanine—tRNA ligase
- EC 6.1.1.8: deleted
- EC 6.1.1.9: valine—tRNA ligase
- EC 6.1.1.10: methionine—tRNA ligase
- EC 6.1.1.11: serine—tRNA ligase
- EC 6.1.1.12: aspartate—tRNA ligase
- EC 6.1.1.13: D-alanine-poly(phosphoribitol) ligase
- EC 6.1.1.14: glycine—tRNA ligase
- EC 6.1.1.15: proline—tRNA ligase
- EC 6.1.1.16: cysteine—tRNA ligase
- EC 6.1.1.17: glutamate—tRNA ligase
- EC 6.1.1.18: glutamine—tRNA ligase
- EC 6.1.1.19: arginine—tRNA ligase
- EC 6.1.1.20: phenylalanine—tRNA ligase
- EC 6.1.1.21: histidine—tRNA ligase
- EC 6.1.1.22: asparagine—tRNA ligase
- EC 6.1.1.23: aspartate—tRNAAsn ligase
- EC 6.1.1.24: glutamate—tRNAGln ligase
- EC 6.1.1.25: lysine—tRNAPyl ligase
[edit] EC 6.2: Forming Carbon-Sulfur Bonds
[edit] EC 6.2.1: Acid-Thiol Ligases
- EC 6.2.1.1: acetate—CoA ligase
- EC 6.2.1.2: butyrate—CoA ligase
- EC 6.2.1.3: long-chain-fatty-acid—CoA ligase
- EC 6.2.1.4: succinate—CoA ligase (GDP-forming)
- EC 6.2.1.5: succinate—CoA ligase (ADP-forming)
- EC 6.2.1.6: glutarate—CoA ligase
- EC 6.2.1.7: cholate—CoA ligase
- EC 6.2.1.8: oxalate—CoA ligase
- EC 6.2.1.9: malate—CoA ligase
- EC 6.2.1.10: acid—CoA ligase (GDP-forming)
- EC 6.2.1.11: biotin—CoA ligase
- EC 6.2.1.12: 4-coumarate—CoA ligase
- EC 6.2.1.13: acetate—CoA ligase (ADP-forming)
- EC 6.2.1.14: 6-carboxyhexanoate—CoA ligase
- EC 6.2.1.15: arachidonate—CoA ligase
- EC 6.2.1.16: acetoacetate—CoA ligase
- EC 6.2.1.17: propionate—CoA ligase
- EC 6.2.1.18: citrate—CoA ligase
- EC 6.2.1.19: long-chain-fatty-acid—luciferin-component ligase
- EC 6.2.1.20: long-chain-fatty-acid—(acyl-carrier-protein) ligase
- EC 6.2.1.21: covered by EC 6.2.1.30
- EC 6.2.1.22: (citrate (pro-3S)-lyase) ligase
- EC 6.2.1.23: dicarboxylate—CoA ligase
- EC 6.2.1.24: phytanate—CoA ligase
- EC 6.2.1.25: benzoate—CoA ligase
- EC 6.2.1.26: o-succinylbenzoate—CoA ligase
- EC 6.2.1.27: 4-hydroxybenzoate—CoA ligase
- EC 6.2.1.28: 3a,7a-dihydroxy-5b-cholestanate—CoA ligase
- EC 6.2.1.29: deleted now EC 6.2.1.7
- EC 6.2.1.30: phenylacetate—CoA ligase
- EC 6.2.1.31: 2-furoate—CoA ligase
- EC 6.2.1.32: anthranilate—CoA ligase
- EC 6.2.1.33: 4-chlorobenzoate—CoA ligase
- EC 6.2.1.34: trans-feruloyl-CoA synthase
[edit] EC 6.3: Forming Carbon-Nitrogen Bonds
[edit] EC 6.3.1: Acid-Ammonia (or Amine) Ligases (Amide Synthases)
- EC 6.3.1.1: aspartate—ammonia ligase
- EC 6.3.1.2: glutamate—ammonia ligase
- EC 6.3.1.3: now EC 6.3.4.13
- EC 6.3.1.4: aspartate—ammonia ligase (ADP-forming)
- EC 6.3.1.5: NAD+ synthase
- EC 6.3.1.6: glutamate—ethylamine ligase
- EC 6.3.1.7: 4-methyleneglutamate—ammonia ligase
- EC 6.3.1.8: glutathionylspermidine synthase
- EC 6.3.1.9: trypanothione synthase
- EC 6.3.1.10: adenosylcobinamide-phosphate synthase
- EC 6.3.1.11: glutamate—putrescine ligase
[edit] EC 6.3.2: Acid—Amino-Acid Ligases (Peptide Synthases)
- EC 6.3.2.1: pantoate—b-alanine ligase
- EC 6.3.2.2: glutamate—cysteine ligase
- EC 6.3.2.3: glutathione synthase
- EC 6.3.2.4: D-alanine—D-alanine ligase
- EC 6.3.2.5: phosphopantothenate—cysteine ligase
- EC 6.3.2.6: phosphoribosylaminoimidazolesuccinocarboxamide synthase
- EC 6.3.2.7: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate—L-lysine ligase
- EC 6.3.2.8: UDP-N-acetylmuramate—L-alanine ligase
- EC 6.3.2.9: UDP-N-acetylmuramoylalanine—D-glutamate ligase
- EC 6.3.2.10: UDP-N-acetylmuramoylalanyl-tripeptide—D-alanyl-D-alanine ligase
- EC 6.3.2.11: carnosine synthase
- EC 6.3.2.12: dihydrofolate synthase
- EC 6.3.2.13: UDP-N-acetylmuramoylalanyl-D-glutamate—2,6-diamino-pimelate ligase
- EC 6.3.2.14: 2,3-dihydroxybenzoate—serine ligase
- EC 6.3.2.15: deleted, due to EC 6.3.2.10
- EC 6.3.2.16: D-alanine—alanyl-poly(glycerolphosphate) ligase
- EC 6.3.2.17: tetrahydrofolate synthase
- EC 6.3.2.18: g-glutamylhistamine synthase
- EC 6.3.2.19: ubiquitin—protein ligase
- EC 6.3.2.20: indoleacetate—lysine synthetase
- EC 6.3.2.21: ubiquitin—calmodulin ligase
- EC 6.3.2.22: diphthine—ammonia ligase
- EC 6.3.2.23: homoglutathione synthase
- EC 6.3.2.24: tyrosine—arginine ligase
- EC 6.3.2.25: tubulin—tyrosine ligase
- EC 6.3.2.26: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase
- EC 6.3.2.27: aerobactin synthase
[edit] EC 6.3.3: Cyclo-Ligases
- EC 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase
- EC 6.3.3.2: 5-formyltetrahydrofolate cyclo-ligase
- EC 6.3.3.3: dethiobiotin synthase
- EC 6.3.3.4: (carboxyethyl)arginine b-lactam-synthase
[edit] EC 6.3.4: Other Carbon-Nitrogen Ligases
- EC 6.3.4.1: GMP synthase
- EC 6.3.4.2: CTP synthase
- EC 6.3.4.3: formate—tetrahydrofolate ligase
- EC 6.3.4.4: adenylosuccinate synthase
- EC 6.3.4.5: argininosuccinate synthase
- EC 6.3.4.6: urea carboxylase
- EC 6.3.4.7: ribose-5-phosphate—ammonia ligase
- EC 6.3.4.8: imidazoleacetate—phosphoribosyldiphosphate ligase
- EC 6.3.4.9: biotin—(methylmalonyl-CoA-carboxytransferase) ligase
- EC 6.3.4.10: biotin—(propionyl-CoA-carboxylase (ATP-hydrolysing)) ligase
- EC 6.3.4.11: biotin—(methylcrotonoyl-CoA-carboxylase) ligase
- EC 6.3.4.12: glutamate—methylamine ligase
- EC 6.3.4.13: phosphoribosylamine—glycine ligase
- EC 6.3.4.14: biotin carboxylase
- EC 6.3.4.15: biotin—(acetyl-CoA-carboxylase) ligase
- EC 6.3.4.16: carbamoyl-phosphate synthase (ammonia)
- EC 6.3.4.17: formate—dihydrofolate ligase
[edit] EC 6.3.5: Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor
- EC 6.3.5.1: NAD+ synthase (glutamine-hydrolysing)
- EC 6.3.5.2: GMP synthase (glutamine-hydrolysing)
- EC 6.3.5.3: phosphoribosylformylglycinamidine synthase
- EC 6.3.5.4: asparagine synthase (glutamine-hydrolysing)
- EC 6.3.5.5: carbamoyl-phosphate synthase (glutamine-hydrolysing)
- EC 6.3.5.6: asparaginyl-tRNA synthase (glutamine-hydrolysing)
- EC 6.3.5.7: glutaminyl-tRNA synthase (glutamine-hydrolysing)
- EC 6.3.5.8: aminodeoxychorismate synthase
- EC 6.3.5.9: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing)
- EC 6.3.5.10: adenosylcobyric acid synthase (glutamine-hydrolysing)
[edit] EC 6.4: Forming Carbon-Carbon Bonds
- EC 6.4.1.1: pyruvate carboxylase
- EC 6.4.1.2: acetyl-CoA carboxylase
- EC 6.4.1.3: propionyl-CoA carboxylase
- EC 6.4.1.4: methylcrotonoyl-CoA carboxylase
- EC 6.4.1.5: geranoyl-CoA carboxylase
- EC 6.4.1.6: acetone carboxylase
[edit] EC 6.5: Forming Phosphoric Ester Bonds
- EC 6.5.1.1: DNA ligase (ATP)
- EC 6.5.1.2: DNA ligase (NAD+)
- EC 6.5.1.3: RNA ligase (ATP)
- EC 6.5.1.4: RNA-3'-phosphate cyclase
[edit] EC 6.6: Forming Nitrogen—Metal Bonds
[edit] EC 6.6.1: Forming Coordination Complexes
Active site - Binding site - Catalytically perfect enzyme - Coenzyme - Cofactor - EC number - Enzyme catalysis - Enzyme kinetics - Enzyme inhibitor - Lineweaver-Burk plot - Michaelis-Menten kinetics
EC1 Oxidoreductases,O+R+D/list (alcohol oxidoreductases, CH-CH oxidoreductases, peroxidase, oxygenase) - EC2 Transferases/list (methyltransferase, acyltransferase, glycosyltransferase, transaminase, phosphotransferase, polymerase, kinase) - EC3 Hydrolases/list (esterase, DNA glycosylases, glycosidase, protease, acid anhydride hydrolases) - EC4 Lyases/list (carboxy-lyases, aldolase, dehydratase, synthase, adenylate cyclase, guanylate cyclase) - EC5 Isomerases/list (mutase, topoisomerase) - EC6 Ligases/list (DNA ligase, aminoacyl tRNA synthetase)
