Lymphoma

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This article is about lymphoma in humans. For the disease in dogs, cats, and ferrets, see lymphoma in animals.

Lymphoma is a variety of cancer that originates in lymphocytes or, more rarely, of histiocytes. Collectively, these cell types form the reticuloendothelial system and circulate in the vessels of the lymphatic system. Similar to lymphocytes, there are many types of lymphoma. Lymphomas are part of the broad group of diseases called hematological neoplasms.

Traditionally, Lymphoma is classified as Hodgkin's lymphoma, discovered by Thomas Hodgkin in 1832, and non-Hodgkin's lymphoma (all other types of lymphoma). Modern classifications of lymphoma are more sophisticated than this simple scheme.

1 Prevalence
2 Classification
3 For diagnosis, etiology, staging, prognosis, and treatment
4 See also
5 References
6 External links

[edit] Prevalence

According to the U.S. National Institutes of Health, lymphomas account for about five percent of all cases of cancer in the United States, and Hodgkin's disease in particular accounts for less than one percent of all cases of cancer in the United States.

Because the lymphatic system is part of the body's immune system, patients with weakened immune system, such as from HIV infection or from certain drugs or medication, also have a higher incidence of lymphoma.

[edit] Classification

[edit] WHO classification

The WHO Classification is the latest classification of lymphoma, published by the World Health Organization in 2001. It was based upon the "Revised European-American Lymphoma classification" (REAL).

This classification attempts to classify lymphomas by cell type, i.e. the normal cell type that most closely resembles the tumour. They are classified in three large groups: the B cell tumours, the T cell and natural killer cell tumours, Hodgkin lymphoma, and other minor groups: (ICD-O codes are provided where available)

[edit] Mature B cell neoplasms

DNA-microarray analysis of Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. Colors indicate levels of expression; green indicates genes that are overexpressed in normal cells compared to lymphoma cells and red indicates genes that are overexpressed in lymphoma cells compared to normal cells.

- Chronic lymphocytic leukemia/small lymphocytic lymphoma
- B-cell prolymphocytic leukemia
- Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia
- Splenic marginal zone lymphoma
- Plasma cell neoplasms
  - Plasma cell myeloma
  - Plasmacytoma
  - Monoclonal immunoglobulin deposition diseases
  - Heavy chain diseases
- Extranodal marginal zone B cell lymphoma (MALT lymphoma)
- Nodal marginal zone B cell lymphoma
- Follicular lymphoma
- Mantle cell lymphoma
- Diffuse large B cell lymphoma
- Mediastinal (thymic) large B cell lymphoma
- Intravascular large B cell lymphoma
- Primary effusion lymphoma
- Burkitt lymphoma/leukemia
- lymphomatoid granulomatosis

[edit] Mature T cell and natural killer (NK) cell neoplasms

- T cell prolymphocytic leukemia
- T cell large granular lymphocytic leukemia
- Aggressive NK cell leukemia
- Adult T cell leukemia/lymphoma
- Extranodal NK/T cell lymphoma, nasal type
- Enteropathy-type T cell lymphoma
- Hepatosplenic T cell lymphoma
- Blastic NK cell lymphoma
- Mycosis fungoides/Sezary syndrome
- Primary cutaneous CD30-positive T cell lymphoproliferative disorders
  - Primary cutaneous anaplastic large cell lymphoma
  - Lymphomatoid papulosis
- Angioimmunoblastic T cell lymphoma
- Peripheral T cell lymphoma, unspecified
- Anaplastic large cell lymphoma

[edit] Hodgkin Lymphoma

- Nodular lymphocyte-predominant Hodgkin lymphoma
- Classical Hodgkin lymphoma
  - Nodular sclerosis
  - Mixed cellularity
  - Lymphocyte-rich
  - Lymphocyte depleted or not depleted

[edit] Immunodeficiency-associated lymphoproliferative disorders

- Associated with a primary immune disorder
- Associated with the Human Immunodeficiency Virus (HIV)
- Post-transplant
- Associated with Methotrexate therapy

[edit] Histiocytic and dendritic cell neoplasms

- Histiocytic sarcoma
- Langerhans cell histiocytosis
- Langerhans cell sarcoma
- Interdigitating dendritic cell sarcoma/tumour
- Follicular dendritic cell sarcoma/tumour
- Dendritic cell sarcoma, unspecified

[edit] Working formulation

The Working Formulation, published in 1982, is primarily descriptive. It is still occasionally used, but has been superseded by the WHO classification, above.

[edit] Low grade

Malignant Lymphoma, small lymphocytic (chronic lymphocytic leukemia)
Malignant Lymphoma, follicular, predominantly small cleaved cell
Malignant Lymphoma, follicular, mixed (small cleaved and large cell)

[edit] High grade

Malignant Lymphoma, large cell, immunoblastic
Malignant Lymphoma, lymphoblastic
Malignant Lymphoma, small non-cleaved cells (Burkitt's lymphoma)

[edit] Miscellaneous

[edit] Other classification systems

ICD-O (codes 9590-9999, details at [1]) (archive link, was dead)
ICD-10 (codes C81-C96, details at [2])

[edit] For diagnosis, etiology, staging, prognosis, and treatment

Please see separate links to Hodgkin's lymphoma and non-Hodgkin's lymphoma.

[edit] See also

[edit] References

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Any material not supported by sources may be challenged and removed at any time. This article has been tagged since October 2006.