P2Y12
From Wikipedia, the free encyclopedia
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purinergic receptor P2Y, G-protein coupled, 12
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| Identifiers | |
| Symbol | P2RY12 |
| HUGO | 18124 |
| Entrez | 64805 |
| OMIM | 600515 |
| RefSeq | NM_022788 |
| UniProt | Q9H244 |
| PDB | 1VZ1 |
| Other data | |
| Locus | Chr. 3 q24-q25 |
P2Y12 is a chemoreceptor for adenosine diphosphate (ADP) found on the cell surface of blood platelet cells. Belongs to group of nucleotide or purinergic receptors. It is an important regulator in blood platelet coagulation. The drug Clopidogrel binds to this receptor and is marketed as a platelet anticoagulant. In an April 2006 article, a team of researchers published a study of the role of platelet-transported serotonin in liver regeneration, in which this method of platelet anticoagulant therapy was used [1].
