Piroxicam

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Piroxicam
Systematic (IUPAC) name
(8E)-8-[hydroxy-(pyridin-2-ylamino)methylidene]- 9-methyl-10,10-dioxo-10λ⁶-thia-9-azabicyclo[4.4.0] deca-1,3,5-trien-7-one
Identifiers
CAS number	36322-90-4
ATC code	M01AC01 M02 AA07, S01 BC06
PubChem	5280452
DrugBank	APRD01187
Chemical data
Formula	C₁₅H₁₃N₃O₄S
Mol. mass	331.348 g/mol
Pharmacokinetic data
Bioavailability	?
Metabolism	4 to 10% renal
Half life	30 to 86 hours
Excretion	4 to 10% renal
Therapeutic considerations
Pregnancy cat.	C, D if used in the third trimester or near delivery
Legal status
Routes	?

Piroxicam (marketed in the U.S. under the trade name Feldene) is a non-steroidal anti-inflammatory drug used to relieve the symptoms of Rheumatoid and Osteoarthritis, primary dysmenorrhoea, Post Operative Pain; and act as an analgesic, especially where there is an inflammatory component. It is also used in veterinary medicine to treat certain neoplasias expressing cyclooxygenase (COX) receptors, such as bladder, colon, and prostate cancers.

[edit] Mechanism of action

Main article: Non-steroidal anti-inflammatory drug

Piroxicam is an NSAID and, as such, is a non-selective COX inhibitor possessing both analgesic and antipyretic properties. It undergoes entero-hepatic circulation.

[edit] Adverse effects

Main article: Non-steroidal anti-inflammatory drug

Piroxicam use can result in gastrointestinal toxicity, tinnitus, dizziness, headache, rash, and pruritus. The most severe adverse reactions are peptic ulceration and gastrointestinal bleeding. Approximately 30% of all patients receiving daily doses of 20 mg of piroxicam experience side effects.^[1]