Rosenmund reduction
From Wikipedia, the free encyclopedia
The Rosenmund reduction is a chemical reaction that reduces an acid halide to an aldehyde using hydrogen gas over palladium-on-carbon poisoned with barium sulfate.[1] [2] [3]
The catalyst must be poisoned because otherwise the catalyst is too active and will reduce the acid chloride to a primary alcohol.
Diisobutylaluminium hydride (DIBALH) can also reduce acid chlorides to aldehydes.
[edit] See also
- Grundmann aldehyde synthesis
[edit] References
- ^ Rosenmund, K. W. Ber. 1918, 51, 585.
- ^ Rosenmund, K. W.; Zetzsche, F. Ber. 1921, 54, 425.
- ^ Mosettig, E.; Mozingo, R. Org. React. 1948, 4, 362. (Review)
- Organic Syntheses, Coll. Vol. 6, p.1007 (1988); Vol. 51, p.8 (1971). (Article)
