Sideroblastic
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Sideroachrestic anemia or sideroblastic anemia are any of a heterogeneous group of acquired and hereditary anemias with diverse clinical manifestations; commonly characterized by large numbers of ringed sideroblasts in the bone marrow, ineffective erythropoiesis, variable proportions of hypochromic erythrocytes in the peripheral blood, and usually increased levels of tissue iron. The two most common kinds are hereditary sideroblastic anemia and refractory sideroblastic anemia.
[edit] Laboratory diagnosis
The anemia is moderate to severe and dimorphic with marked anisocytosis and poikilocytosis. Basophilic stippling is marked and target cells are common. Pappenheimer bodies are present. The MCV is increased. The RDW is increased with the red blood cell histogram shifted to the left. Leukocytes and platelets are normal. Bone marrow shows erythroid hyperplasia with a maturation arrest.
In excess of 40% of the developing erythrocytes are ringed sideroblasts. Serum iron, percentage saturation and ferritin are increased. The TIBC is normal to decreased. Stainable marrow hemosiderin is increased.
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