Syk
From Wikipedia, the free encyclopedia
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spleen tyrosine kinase
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| Identifiers | |
| Symbol | SYK |
| HUGO | 11491 |
| Entrez | 6850 |
| OMIM | 600085 |
| RefSeq | NM_003177 |
| UniProt | P43405 |
| Other data | |
| Locus | Chr. 9 q22 |
Syk, along with Zap-70, is a member of the syk family of tyrosine kinases. These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain.
While syk and Zap-70 are primarily expressed in hematopoietic tissues, there is expression of syk in a variety of tissues. Within B and T cells respectivly, Syk and Zap-70 transmit signals from the B-Cell receptor and T-Cell receptor.
Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, CD33, Fc Receptor, and various integrins.
[edit] External links
Abelson leukemia virus protein - c-Kit - C-MET - Flt3 - Receptor tyrosine kinase - Janus kinase - Src (Lck) - Syk - ZAP-70
