GATA1
From Wikipedia, the free encyclopedia
GATA1 is an important transcription factor involved in cell growth and cancer. It is essential for erythroid(red blood cell) and megakaryocytic development and mice without GATA1 die as embryos. The molecule contains three domains the C-finger the N-finger and the Activation Domain. The C-finger, named for being near the C-terminal, has a Zinc finger DNA binding domain. The N-finger, named for being near the N-terminal also binds DNA and a cofactor named FOG-1. The Activation Domain is responsible for GATA1's strong transcriptional activation. The gene for GATA1 is on the X-chromosome.
