Gene nomenclature

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There is currently a lack of clarity regarding gene nomenclature across numerous scientific publications and public databases (Fundel and Zimmer, 2006 ^[1]). Below are detailed the recommended notation provided by the respective genome nomenclature committees for each organism.

Human gene and protein names and symbols follow current HGNC nomenclature^[2] as show in the NCBI Gene Database^[3].

To summarise, gene symbols are italicized with all letters in uppercase. Proteins designations are the same as the gene symbol, but not italicised and all letters in uppercase. mRNA and cDNA use the gene symbol and formatting conventions.

Mouse gene and protein names and symbols follow current MGNC nomenclature ^[4] as shown in the NCBI Gene Database^[5].

To summarise, gene symbols are italicised with first letter uppercase the remaining letters in lower case. Proteins designations are the same as the gene symbol, but not italicized with all letters in uppercase. mRNA and cDNA use the gene symbol and formatting conventions.

Xenopus gene and protein names and symbols are in the process of being converted to HGNC nomenclature ^[6] as shown in the Xenbase Gene database ^[7].

To summarise, gene symbols are italicised with all letters in lowercase. Proteins designations are the same as the gene symbol, but not italicized and all letters in uppercase. Names and symbols of Xenopus genes not yet in the Xenbase Gene database should currently follow nomenclature most frequently used in the literature.

[edit] References

1. ^ http://www.biomedcentral.com/1471-2105/7/372
2. ^ Human Genome Nomenclature Committee[1]
3. ^ NCBI Gene Database[2]
4. ^ Mouse Genome Nomenclature Committee[3]
5. ^ NCBI Gene Database[4]
6. ^ Xenbase Suggested Xenopus Gene Name Guidelines[5]
7. ^ Xenbase Gene Database[6]