George Emil Palade

From Wikipedia, the free encyclopedia

Dr. Palade won the Nobel Prize in 1974.

George Emil Palade (b. November 19, 1912, in Iaşi) is a Romanian-born American cell biologist. In 1974, he shared the Nobel Prize in Physiology or Medicine with Albert Claude and Christian de Duve, for his discoveries concerning the structure and function of organelles in biological cells.

[edit] Biography

George Palade received a M.D. in 1940 from the Carol Davila School of Medicine of the University of Bucharest, Romania. He was a member of the faculty of that school until 1945 when he went to the United States for postdoctoral studies. There, he joined Prof. Albert Claude at the Rockefeller Institute for Medical Research.

In 1952, Palade became a naturalized citizen of the United States. He was a professor at the Rockefeller Institute (1958-1973), Yale University Medical School (1973-1990), and University of California, San Diego (1990-present).

Alongside the Nobel Prize, he received the National Medal of Science in 1986.

At the Rockefeller Institute, Palade used electron microscopy to study the internal organization of such cell structures as mitochondria, chloroplasts, the Golgi apparatus, and others. His most important discovery was related to ribosomes.

His name has become attached to the Weibel-Palade bodies (a storage organelle unique to the endothelium, containing von Willebrand factor and various proteins) which he described together with the Swiss anatomist Ewald R. Weibel (Weibel ER, Palade GE. New cytoplasmic components in arterial endothelia. J Cell Biol 1964;23:101-112).