Glutathione reductase

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glutathione reductase
Identifiers
Symbol	GSR
HUGO	4623
Entrez	2936
OMIM	138300
RefSeq	NM_000637
UniProt	P00390
Other data
EC number	1.8.1.7
Locus	Chr. 8 p21.1

Glutathione reductase is an enzyme (EC 1.8.1.7) which reduces glutathione disulphide (GSSG) to the sulfhydryl form GSH. For every mole of GSSG one mole of NADPH is required. The NADPH is generated through the Pentose phosphate pathway. In cells exposed to high levels of oxidative stress, like erythrocytes, up to 10% of the glucose consumption may be used for production of the NADPH needed for this reaction.