Glutathione reductase
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glutathione reductase
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| Identifiers | |
| Symbol | GSR |
| HUGO | 4623 |
| Entrez | 2936 |
| OMIM | 138300 |
| RefSeq | NM_000637 |
| UniProt | P00390 |
| Other data | |
| EC number | 1.8.1.7 |
| Locus | Chr. 8 p21.1 |
Glutathione reductase is an enzyme (EC 1.8.1.7) which reduces glutathione disulphide (GSSG) to the sulfhydryl form GSH. For every mole of GSSG one mole of NADPH is required. The NADPH is generated through the Pentose phosphate pathway. In cells exposed to high levels of oxidative stress, like erythrocytes, up to 10% of the glucose consumption may be used for production of the NADPH needed for this reaction.
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