Gomberg-Bachmann reaction
From Wikipedia, the free encyclopedia
The Gomberg-Bachmann reaction is an aryl - aryl coupling reaction via a diazonium salt.[1][2][3]
The arene compound 1 (here benzene) is coupled with base with the diazonium salt 2 to the biaryl 3. Many aromats have been tested but yields are generally low (less than 40%) given the many side-reactions of diazonium salts. One intramolecular variation which gives better results is the Pschorr reaction. The reaction carries the name of Moses Gomberg.
[edit] References
- ^ M Gomberg, W E Bachmann. J. Am. Chem. Soc. 1924, 42, 2339-2343. (DOI:10.1021/ja01675a026)
- ^ W Pötsch. Lexikon bedeutender Chemiker (VEB Bibliographisches Institut Leipzig, 1989) (ISBN 3817110553 )
- ^ M B Smith, J March. March's Advanced Organic Chemistry (Wiley, 2001) (ISBN 0-471-58589-0)
[edit] See also
- Graebe-Ullmann synthesis
- Meerwein arylation
- Pschorr reaction
- Sandmeyer reaction
