Talk:Hematopoietic stem cell transplantation
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[edit] BMT article history
Older versions of this article (prior to having it's title changed from BMT to HSCT) can be viewed on the old BMT history page.Mfero 16:31, 1 March 2007 (UTC)
[edit] BMT article title
I've expanded most of the sections on the Bone Marrow Transplant page. My apologies if I messed anything up.
I'd like to know if anyone has an opinion about moving the page to "Hematopoietic Stem Cell Transplant"? "Bone mone marrow transplant" would then be a redirect. Even though HSCT is more modern and accurate than BMT for the topic it is still a little more awkward. Also there are a huge number of links to this page and probably many of them should be changed.
- No, keep it here. Most lay readers will not have a clue what a haematopoeitic stem cell is, and the fine distinctions between BMT and HSCT. Just redirect HSCT here. JFW | T@lk 06:48, 11 July 2005 (UTC)
- I totally agree with the first guy, that this article really should be titled HSCT, with a redirect from the bone marrow transplant title to HSCT main page. Very few patients get bone marrow transplants anymore, since peripheral blood stem cell transplants are safer and more effective...I think I'm going to do it tonight, since this doesn't seem like a very active concern--64.166.186.217 23:33, 15 February 2007 (UTC)
I'd be fine with moving it - this comes up a lot: whether to use the more medically exact and correct term, or the one more likely to be recognizable to a wide audience. I think moving the page to HSCT, and leaving "bone marrow transplant" as a redirect would be fine. To quibble, stem cells are more effective for a lot of indications, but in conditions where graft-vs.-tumor is not a consideration (eg aplastics), bone marrow is still a preferred source. MastCell 23:46, 15 February 2007 (UTC)
Hi--I moved and updated the BMT page to the HSCT page, updated links and talk page. Someone had to move HSCT into the 1990s! I think MastCell is correct about the preference for BMT in AA, and that's an excellent point that somehow should be inserted in the mainpage. I will verify this with my friendly neighborhood transplanter.--Dr.michael.benjamin 06:55, 20 February 2007 (UTC)
[edit] Conditions treated with BMT
Myelodysplasia is a common indication for allogeneic transplants in adults, second only to AML in terms of frequency. The risk/benefit ratio depends on the age of the patient, donor availability, features indicating a high risk of transformation to AML, and the expertise level of the transplant center. Mfero 20:59, 17 September 2005 (UTC)
[edit] General anesthetic?
"In the case of a bone marrow transplant (BMT), the HSC are removed from a large bone of the donor, typically the pelvis, through a large needle that reaches the center of the bone. The technique is referred as a bone marrow harvest and is performed with general anesthesia because literally hundreds of insertions of the needle are required to obtain sufficient material."
I thought this was actually done under a local, which would explain why people say that donating bone marrow is extremely painful. Can someone clear this up for me? --El Zilcho 17:18, 22 March 2006 (UTC)
- Bone marrow harvests are generally done in the operating room under general anesthesia. On the other hand, a stem cell transplant can be also done through a peripheral blood collection of stem cells (after the bone marrow has been stimulated with medication). Andrew73 19:32, 22 March 2006 (UTC)
[edit] Forensic Post
ChristineD, please site a credible reference for your last edit. A fictional one will not suffice as an accurate source. Ktinga
- Agreed... I've heard of this happening on, say, Law and Order, but I'm not aware of any real-life cases. If one could be cited, then by all means let's include it. Until then, I think describing it as an "eventuality" is a little inappropriate. MastCell 21:47, 16 October 2006 (UTC)
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- [Mammalian Red Blood] Do not have DNA or a nucleus so it appears to be fiction. Ktinga 16:13 17 Oct 2006 (UTC)
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- To be fair, after a transplant all cellular elements of the blood are replaced by donor cells, including the white cells, which contain DNA and are presumably the substrate for forensic DNA testing. MastCell 18:16, 17 October 2006 (UTC)
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The fictional reference wasn't intended as a source, just as an example (could do a section BMT in literature?). I read an article in a newspaper (but I have no memory of where or when) in which a real life police person said this was a real problem. That was the basis for including this section. I hoped that once it was out there the reference could be added by someone who knows more.
Anyway I've looked it up on Pub med now and the abstract for this article (What do the X and Y chromosomes tell us about sex and gender in forensic case analysis? ) mentions it ('Problems may arise not only from false detection (or non-detection) of amelogenin-specific fragments, but also in cases of chimerism (bone marrow transplants) or micro chimerism (pregnant women carrying male fetuses)...'). I don't have online access to the papers from home to find an original source for this particular question, however, I will see to it soonest and then revert
- but I'm not aware of any real-life cases
I think the idea of thinking about eventualites is so that it doesn't happen in real life. This is a real issue but hopefully by increasing awareness of it, any real life cases can be resolved quickly and not end up reported in the media as a miscarriage of justice. ChristineD 21:06, 29 October 2006 (UTC)
[edit] External Links
Hi. I tried to add an external link to the EBMT website, but it was removed. I would just like to know why it doesn't qualify and where could it be added? Thanks. Melisa —The preceding unsigned comment was added by Mfero (talk • contribs).
- A link to EBMT should be fine. Not sure why it was removed (perhaps an innocent casualty of a mass spam deletion), but go ahead and re-add it. MastCell 17:23, 1 March 2007 (UTC)
