Hepoxilin
From Wikipedia, the free encyclopedia
Hepoxilins are eicosanoid hormones involved in inflammation. They derive from arachidonic acid via oxidation by the enzyme 12-lipoxygenase. Hepoxilins are differentiated from closely related eicosanoids, the leukotrienes and the lipoxins, in that hepoxolins have no conjugated double bonds. In the skin, they are pro-inflammatory , but in neutrophils they are anti-inflammatory.[1] One hepoxilin, HepA3, mediates neutrophil migration across the intestines.[2]
[edit] References
- ^ Christie, William W. (2006). LEUKOTRIENES AND LIPOXINS: Chemistry and Biology. Retrieved on January 4, 2007.
- ^ Randall J. Mrsny, Andrew T. Gewirtz, Dario Siccardi, Tor Savidge , Bryan P. Hurley , James L. Madara, and Beth A. McCormick (2004). Identification of hepoxilin A3 in inflammatory events: A required role in neutrophil migration across intestinal epithelia. Retrieved on January 4, 2007.
 |
This biochemistry article is a stub. You can help Wikipedia by expanding it. |
