Interleukin 11
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interleukin 11
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| Identifiers | |
| Symbol | IL11 |
| HUGO | 5966 |
| Entrez | 3589 |
| OMIM | 147681 |
| RefSeq | NP_000632 |
| UniProt | P20809 |
| Other data | |
| Locus | Chr. 19 q13.3-q13.4 |
Interleukin 11 (IL-11) is a cytokine (first isolated in 1990) that originates from bone marrow stroma and activates B cells and megakaryocytes.[1] It is also known under the names Adipogenesis inhibitory factor (AGIF)[2] and Oprelvekin. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induce acute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cell proliferation and differentiation and could be use as a therapeutic for osteoporosis. Besides from lymphopoietic/hematopoietic and osteotrophic properties, it has functions in many tissues such as brain, gut and testis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thickness and strength of long bones. Compared to other interleukins, IL-11 relatively under-characterized.
The human IL-11 gene, consisting of 5 exons and 4 introns, is located on chromosome 19.[3] IL-11 belongs to the IL-6 superfamily.
[edit] References
- ^ Paul,S.R., et al., Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proceeding of the National Academy of Science U.S.A., 1990, Volume 87 pages 7512-7516.
- ^ Kawashima,I et al., Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin-11. FEBS Letters, 1991, Volume 283, pages 199-202.
- ^ McKinley et al., Genomic sequence and chromosomal location of human interleukin-11 gene (IL11). Genomics, 1992, Volume 13, pages 814-819.
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